N-甲基-N'-(2,4-二甲基苯基)硫脲 | 13278-55-2

• 物质功能分类: 化学试剂 - 有机试剂 - 硫脲
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-甲基-N'-(2,4-二甲基苯基)硫脲
• 中文别名: 3-甲基-1-(2,4-二甲基苯基)硫脲；N-甲基-N’-(2,4-二甲基苯基)硫脲
• 英文名称: N-(2,4-dimethyl-phenyl)-N'-methyl-thiourea
• 英文别名: N-methyl-N'-(2,4-dimethylphenyl)thiourea；N-(2,4-dimethyl-phenyl)-N'-methyl-thiourea；N-(2,4-Dimethyl-phenyl)-N'-methyl-thioharnstoff；3-methyl-1-(2,4-xylyl)thiourea；N-(2,4-dimethylphenyl)-N'-methylthiourea；1-(2,4-dimethylphenyl)-3-methylthiourea
• CAS: 13278-55-2
• 化学式: C₁₀H₁₄N₂S
• mdl: MFCD03208875
• 分子量: 194.301
• InChiKey: HZAOAIZJMMTSFN-UHFFFAOYSA-N

物化性质

• 沸点：
  277.2±50.0 °C(Predicted)
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  N-甲基-N'-(2,4-二甲基苯基)硫脲 以 甲苯 为溶剂， 反应 4.0h， 以68%的产率得到1-异硫氰酸基-2,3-二甲基苯
  参考文献：
  名称：

  A Simple Construction of 2-Phenylimino-1,3-thiazolidin-4-ones

  摘要：

  A new methodology for the construction of 2-phenylimino-1,3-thiazolidin-4-one skeleton is described. Reaction of maleic anhydride (5a) or maleimides (5b, 5c) with thiourea (6) gave the corresponding 2-imino-1,3-thiazolidin-4-ones (7) and (9) respectively. The reaction proceeded with high yield in polar solvents. In non-polar solvents at high temperature, however, isothiocyanate (8) was formed as a by-product presumably by the pyrolysis of thiourea (6). The proposed mechanism of the reaction was discussed.

  DOI：

  10.3987/com-01-9227
• 作为产物：
  描述：

  bis(2,4-dimethylphenyl)thiourea 在 乙醇 作用下， 生成 N-甲基-N'-(2,4-二甲基苯基)硫脲
  参考文献：
  名称：

  Hunter; Pride, Journal of the Chemical Society, 1929, p. 944

  摘要：

  DOI：

文献信息

• Thiazoline derivatives
  申请人：Hoechst Aktiengesellschaft

  公开号：US04346088A1

  公开（公告）日：1982-08-24

  Thiazoline derivatives of the general formula I ##STR1## wherein R.sup.1 to R.sup.7 have the specified meanings, physiologically acceptable acid addition salts thereof, processes for their preparation, pharmaceutical preparations based on these compounds and their use for acting on the serum lipoprotein spectrum. The invention moreover relates to compounds of the formulae ##STR2## wherein A, R, R.sup.1 to R.sup.7, Y and Z have the specified meanings.

  通式I的噻唑啉衍生物##STR1##，其中R.sup.1至R.sup.7具有指定的含义，其生理上可接受的酸盐，其制备方法，基于这些化合物的制药制剂以及它们用于作用于血清脂蛋白谱的用途。此外，本发明涉及以下通式的化合物##STR2##，其中A，R，R.sup.1至R.sup.7，Y和Z具有指定的含义。
• Substituted 4,5-dihydroxy-imidazolidine-2-thiones and their use as
  申请人：Bayer Aktiengesellschaft

  公开号：US04173645A1

  公开（公告）日：1979-11-06

  The present invention provides, as compounds, the substituted 4,5-dihydroxy-imidazolidine-2-thiones of the general formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.3, which are selected independently of one another each represent hydrogen, optionally substituted alkyl, optionally substituted alkoxy or halogen and R.sup.4 represents optionally substituted alkyl, cycloalkyl or alkenyl. It has been found that the compounds of this invention have a powerful ectoparasiticidal action, in particular against acarids.

  本发明提供了一种化合物，即一般式为##STR1##的取代的4,5-二羟基咪唑啉-2-硫酮，其中R.sup.1、R.sup.2和R.sup.3是独立选择的氢、可选取代的烷基、可选取代的烷氧基或卤素，而R.sup.4代表可选取代的烷基、环烷基或烯基。发现本发明化合物具有强大的外寄生虫杀虫作用，特别是对螨虫。
• Phenylimino-thiazolines and their use as acaricides
  申请人：Ciba-Geigy Corporation

  公开号：US04079144A1

  公开（公告）日：1978-03-14

  Novel acaricidally effective thiazoline compounds corresponding to the general formula ##STR1## wherein R.sub.1 and R.sub.2, independently of one another, represent chlorine, methyl or ethyl, whereby R.sub.2 can occupy the 4- or 6-position, with the exception that if R.sub.1 and R.sub.2 represent chlorine, R.sub.2 cannot be in the 4-position, R.sub.3 represents a straight-chain or branched-chain alkyl group having 1 to 4 carbon atoms, optionally substituted by alkoxy having 1-2 carbon atoms, or a straight-chain or branched-chain alkenyl group having 3 to 5 carbon atoms, optionally substituted by halogen including the acid addition salts, particularly the hydrochlorides, and compositions containing these compounds, as well as the use of these compounds for combatting mites, particularly ticks.

  该专利涉及到一类对螨虫有杀虫作用的噻唑啉化合物，其化学式为##STR1##其中R1和R2独立地代表氯、甲基或乙基，其中R2可以占据4-或6-位置，但如果R1和R2代表氯，则R2不能在4-位置，R3代表直链或支链烷基，其碳原子数为1到4，可选地被1-2个碳原子的烷氧基取代，或者代表直链或支链烯基，其碳原子数为3到5，可选地被卤素取代，包括酸加成盐，特别是盐酸盐，以及含有这些化合物的组合物，以及这些化合物用于对抗螨虫，特别是对抗蜱虫。
• Tetrahydro-s-triazine thiones
  申请人：Pfizer Inc.

  公开号：US04193994A1

  公开（公告）日：1980-03-18

  A series of tetrahydro-s-triazin-2-[1H]-thiones and their use as acaricidal agents.

  一系列四氢-s-三嗪-2-[1H]-硫酮及其作为杀螨剂的用途。
• Tetrahydro-s-triazine thiones, process for their preparation and acaricidal compositions containing them.
  申请人：Pfizer Limited

  公开号：EP0000640A1

  公开（公告）日：1979-02-07

  Tetrahydro-s-triazine thiones, process for their preparation and acaricidal compositions containing them. Compounds of formula: wherein R is alkyl, cycloalkyl, adamantyl, lower alkenyl, or a lower-alkynyl or a substituted-lower alkyl wherein the substituent is hydroxy, lower alkoxy, lower alkanoyloxy, carbamoyloxy, N-lower alkyl-carbamoyloxy, N-cycloalkyl-carbamoyloxy, N-aryl-carbamoyloxy, thiocarbamoyloxy, N-lower alkyl-thiocarbamoyloxy, N-cycloalkylthiocarbamoyloxy, N-aryl-thiocarbamoyloxy, aryl-sulphonyloxy, mono- or di-lower alkyl-amino or aryl; R1 is lower alkyl or hydroxy-methyl; and X is hydrogen or lower alkyl; and acid addition salts thereof. A process for their preparation and acaricidal compositions.

  四氢-s-三嗪硫醚、其制备方法和含有它们的杀螨组合物。式中的化合物： 其中 R 是烷基、环烷基、金刚烷基、低级烯基或低级炔基或取代的低级烷基，其中取代基是羟基、低级烷氧基、低级烷酰氧基、氨基甲酰氧基、N-低级烷基-氨基甲酰氧基、N-环烷基-氨基甲酰氧基、N-芳基-氨基甲酰氧基、N-下烷基-氨基甲酰氧基、N-环烷基-氨基甲酰氧基、N-芳基-氨基甲酰氧基、硫代氨基甲酰氧基、N-下烷基-硫代氨基甲酰氧基、N-环烷基-硫代氨基甲酰氧基、N-芳基-硫代氨基甲酰氧基、芳基-磺酰氧基、单-或双-下烷基-氨基或芳基； R1 是低级烷基或羟基甲基； X 是氢或低级烷基； 及其酸加成盐。 它们的制备方法和杀螨组合物。