(Z)-5-(4-(2-(2,4-dichlorophenoxy)ethoxy)benzylidene)thiazolidine-2,4-dione | 1345089-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-5-(4-(2-(2,4-dichlorophenoxy)ethoxy)benzylidene)thiazolidine-2,4-dione
• 英文别名: (5Z)-5-[[4-[2-(2,4-dichlorophenoxy)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• CAS: 1345089-56-6
• 化学式: C₁₈H₁₃Cl₂NO₄S
• 分子量: 410.278
• InChiKey: DPHBLBRFFHICSR-SXGWCWSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(2-溴乙氧基)苯甲醛 在 potassium carbonate 、 溶剂黄146 作用下， 以 丙酮 、 甲苯 为溶剂， 生成 (Z)-5-(4-(2-(2,4-dichlorophenoxy)ethoxy)benzylidene)thiazolidine-2,4-dione
  参考文献：
  名称：

  Novel glitazones: glucose uptake and cytotoxic activities, and structure–activity relationships

  摘要：

  In this article, two series of novel glitazones are reported for their synthesis, in vitro glucose uptake activity by the rat hemi-diaphragm, and in vitro cytotoxic activity against human carcinoma HEp-2 (epidermoid carcinoma of the larynx) and A549 (human lung cancer cell line) cells. Some of the compounds exhibit good glucose uptake and cytotoxic activities. Compound 5 with 2,4-dichlorophenol moiety connected to TZD via the two carbon linker has exhibited good glucose uptake activity. One of the compounds exhibits both cytotoxic and glucose uptake activities (compound 4). Illustrations about their synthesis, and in vitro glucose uptake and cytotoxic activities are described along with their structure-activity relationships.Designed, synthesized some novel glitazones and evaluated them for their glucose uptake and cytotoxic activities.

  DOI：

  10.1007/s00044-011-9792-0

文献信息

• Novel glitazones: glucose uptake and cytotoxic activities, and structure–activity relationships
  作者：B. R. Prashantha Kumar、S. Santhosh Kumar、Patel Viral、Ashish Wadhwani、R. Vadivelan、M. N. Satish Kumar、K. Elango、M. J. Nanjan

  DOI：10.1007/s00044-011-9792-0

  日期：2012.9

  In this article, two series of novel glitazones are reported for their synthesis, in vitro glucose uptake activity by the rat hemi-diaphragm, and in vitro cytotoxic activity against human carcinoma HEp-2 (epidermoid carcinoma of the larynx) and A549 (human lung cancer cell line) cells. Some of the compounds exhibit good glucose uptake and cytotoxic activities. Compound 5 with 2,4-dichlorophenol moiety connected to TZD via the two carbon linker has exhibited good glucose uptake activity. One of the compounds exhibits both cytotoxic and glucose uptake activities (compound 4). Illustrations about their synthesis, and in vitro glucose uptake and cytotoxic activities are described along with their structure-activity relationships.Designed, synthesized some novel glitazones and evaluated them for their glucose uptake and cytotoxic activities.