[1-[(2R,3S,4R,5S)-5-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylbutan-2-yl]oxy-[(2R)-2-hydroxybutan-2-yl]phosphinic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: [1-[(2R,3S,4R,5S)-5-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylbutan-2-yl]oxy-[(2R)-2-hydroxybutan-2-yl]phosphinic acid
• 化学式: C₁₉H₃₃N₂O₉P
• 分子量: 464.4
• InChiKey: NTZARAYKEGVIGZ-ZYJCITKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  157
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING CYSTIC FIBROSIS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140155474A1

  公开（公告）日：2014-06-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20150246139A1

  公开（公告）日：2015-09-03

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160354491A1

  公开（公告）日：2016-12-08

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.