6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: 6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one;[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
• 化学式: C54H61Cl2N11O11
• 分子量: 1111.0
• InChiKey: NTNGLMOIBRUPRV-NUBYHRICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  78
• 可旋转键数：
  8
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  256
• 氢给体数：
  4
• 氢受体数：
  15

文献信息

• [EN] BIOCOMPATIBLE POLYMER COMPOSITIONS FOR TISSUE VOID FILLING<br/>[FR] COMPOSITIONS POLYMÈRES BIOCOMPATIBLES POUR REMPLISSAGE DE VIDE TISSULAIRE
  申请人：UNIV RUTGERS

  公开号：WO2014116716A1

  公开（公告）日：2014-07-31

  Biodegradable, bioabsorhahie cross-linked polymer tissue scaffolds for filling a void in human or animal soft tissue, such as a surgical or other wound, are disclosed. Drugs incorporated into the polymer backbone and/or loaded into the matrix are released directly to the target site. Additional non-toxic chemical constituents can be used to tune the hydrophilio hydrophobic and other physical properties of the cross-linked polymer tissue scaffolds, and incorporating brominated or iodinated constituents provides radio-opacity. The radio-opaque cross-linked polymer tissue scaffolds can assist in the targeting of radiation therapy.