申请人:NIPPON KAYAKU KABUSHIKI KAISHA
公开号:EP1630165A1
公开(公告)日:2006-03-01
Novel [1,2,4]triazolo[1,5-a]pyrimidine derivative of the general formula (1): (1) its prodrug or a pharmaceutically acceptable salt thereof, which exhibits an antigen presentation inhibiting activity and is useful as a preventive and/or therapeutic agent for immunological rejection and/or graft versus host reaction in organ/bone marrow transplant, autoimmune disease, allergic disease and/or inflammatory disease and also useful as an anticancer drug or as an immunological tolerance inducer for transplanted organ/transplanted bone marrow.
通式(1)的新型[1,2,4]三唑并[1,5-a]嘧啶衍生物:(1) 其原药或其药学上可接受的盐,具有抗原递呈抑制活性,可作为器官/骨髓移植、自身免疫性疾病、过敏性疾病和/或炎症性疾病中免疫排斥和/或移植物与宿主反应的预防和/或治疗药物,也可作为抗癌药物或移植器官/移植骨髓的免疫耐受诱导剂。