(1S,2S,6R,14R,15S,16S)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-(hydroxymethyl)-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (1S,2S,6R,14R,15S,16S)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-(hydroxymethyl)-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
• 化学式: C₂₉H₄₁NO₄
• 分子量: 467.6
• InChiKey: XAMBQPBRDJEBCI-PGWCRSCVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  73.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• METHOD OF PREPARING BUPRENORPHINE
  申请人：JOHNSON MATHEY PUBLIC LIMITED COMPANY

  公开号：US20140235860A1

  公开（公告）日：2014-08-21

  An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.

  一种改进的制备丁丙诺啡的方法，以及增加丁丙诺啡或其衍生物产量的方法。
• PROCESS FOR THE PREPARATION OF (S)-2-((4R,4AS,6R,7R,7AR,12BS)-7,9-DIMETHOXY-1,2,3,4,5,6,7,7A-OCTAHYDRO-4A,7-ETHANO-4,12-METHANOBENZOFURO[3,2-E]ISOQUINOLIN-6-YL)-3,3-DIMETHYLBUTAN-2-OL
  申请人：Noramco, Inc.

  公开号：US20170101415A1

  公开（公告）日：2017-04-13

  An invention includes a process for the preparation of (S)-2((4R,4aS,6R,7R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-3,3-dimethylbutan-2-ol.

  一项发明涉及一种制备(S)-2((4R,4aS,6R,7R,7aR,12bS)-7,9-二甲氧基-1,2,3,4,5,6,7,7a-八氢-4a,7-乙烯基-4,12-甲氧基苯并呋喃[3,2-e]异喹啉-6-基)-3,3-二甲基丁醇的方法。
• PROCESS FOR PREPARING 7BETA-SUBSTITUTED 6ALPHA,14ALPHA-ETHENOMORPHINANS AND 7BETA-SUBSTITUTED 6ALPHA,14ALPHA-ETHANOMORPHINANS
  申请人：REISCH Helge Alfred

  公开号：US20160068538A1

  公开（公告）日：2016-03-10

  The application is directed to a process for increasing the proportion of 7β-epimer in an 7α/7β-epimer mixture of a 7-substituted 6α,14α-ethenomorphinan or a 7-substituted 6α,14α-ethanomorphinan, and specifically of compounds of Formula (I), wherein G, R 2 -R 4 , and are defined as set forth in the specification. The application is also directed to a process for purifying the 7β-epimer from an 7α/7β-epimer mixture of a 7-substituted 6α,14α-ethenomorphinan or a 7-substituted 6α,14α-ethanomorphinan. The application is also directed to a process for preparing 7β-substituted compounds of Formula V b wherein G and R 2 -R 5 are defined as set forth in the specification.

  本申请涉及一种用于增加7-取代-6α,14α-乙烯吗啡烷或7-取代-6α,14α-乙烷吗啡烷的7α/7β-表异构体混合物中7β-表异构体比例的方法，具体地，涉及公式（I）中G，R2-R4的化合物。本申请还涉及一种从7-取代-6α,14α-乙烯吗啡烷或7-取代-6α,14α-乙烷吗啡烷的7α/7β-表异构体混合物中纯化7β-表异构体的方法。本申请还涉及一种制备公式Vb中G和R2-R5所定义的7β-取代化合物的方法。
• US9624231B2
  申请人：——

  公开号：US9624231B2

  公开（公告）日：2017-04-18