Fmoc-D-Ala-D-Ala-OMe

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-D-Ala-D-Ala-OMe
• 英文别名: methyl (2R)-2-[[(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoyl]amino]propanoate
• 化学式: C₂₂H₂₄N₂O₅
• 分子量: 396.443
• InChiKey: VTNSQHMINZYNMB-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Fmoc-D-Ala-D-Ala-OMe 在 polymer-supported dimethyl-n-octyl-ammonium fluoride 、 吡啶盐酸盐 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.17h， 以95%的产率得到(2R)-1-{[(2R)-1-甲氧基-1-氧代-2-丙基]氨基}-1-氧代-2-丙氯化铵
  参考文献：
  名称：

  A novel strategy for oligopeptide synthesis using a polymer-supported ammonium fluoride

  摘要：

  A novel method for the preparation of oligopeptides with a PS-ammonium fluoride in the solution phase is reported. The synthesis of lipid 11 pentapeptide is efficiently synthesized via a PS-ammonium fluoride without chromatographic purifications. The method reported here is very convenient to synthesize a relatively large amount of oligopeptides with abundantly available Fmoc-protected amino acids in a time efficient manner. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.05.129

文献信息

• BROAD SPECTRUM ANTIBIOTICS
  申请人：Roberts Tucker Curran

  公开号：US20140249073A1

  公开（公告）日：2014-09-04

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broader spectrum of antibiotic bioactivity compared to the natural product. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
• A novel strategy for oligopeptide synthesis using a polymer-supported ammonium fluoride
  作者：Michio Kurosu、Dean C. Crick

  DOI：10.1016/j.tetlet.2006.05.129

  日期：2006.7

  A novel method for the preparation of oligopeptides with a PS-ammonium fluoride in the solution phase is reported. The synthesis of lipid 11 pentapeptide is efficiently synthesized via a PS-ammonium fluoride without chromatographic purifications. The method reported here is very convenient to synthesize a relatively large amount of oligopeptides with abundantly available Fmoc-protected amino acids in a time efficient manner. (c) 2006 Elsevier Ltd. All rights reserved.