(1S,2S)-2-amino-1-phenylpropan-1-ol;(7-chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl) N,N-dimethylcarbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (1S,2S)-2-amino-1-phenylpropan-1-ol;(7-chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl) N,N-dimethylcarbamate
• 化学式: C28H31ClN4O4
• 分子量: 523.0
• InChiKey: QAHZGPIFVCXDAR-YMGBEQBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ABUSE RESISTANT CAPSULE
  申请人：R.P. Scherer Technologies, LLC

  公开号：EP2968129A1

  公开（公告）日：2016-01-20
• [EN] ABUSE RESISTANT CAPSULE<br/>[FR] CAPSULE RÉSISTANTE AUX ABUS
  申请人：WENGNER SIMONE

  公开号：WO2014140231A1

  公开（公告）日：2014-09-18

  The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquillizers, stimulants and narcotics.