4-ethenylsulfonyl-N-[(9-ethylcarbazol-3-yl)methyl]aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-ethenylsulfonyl-N-[(9-ethylcarbazol-3-yl)methyl]aniline
• 化学式: C₂₃H₂₂N₂O₂S
• 分子量: 390.5
• InChiKey: SWYABRMKYFMYRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  59.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] INHIBITORS OF PRMT5 AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE PRMT5 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2014145214A2

  公开（公告）日：2014-09-18

  In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.