8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
• 化学式: C37H35Cl2FN8O
• 分子量: 697.6
• InChiKey: BQZSAETWWHSYGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.69
• 重原子数：
  49
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  72.6
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• CRANIAL DELIVERY OF PHARMACEUTICALS
  申请人：Glia LLC

  公开号：EP2968368A2

  公开（公告）日：2016-01-20
• [EN] CRANIAL DELIVERY OF PHARMACEUTICALS<br/>[FR] ADMINISTRATION CRÂNIENNE DE SUBSTANCES PHARMACEUTIQUES
  申请人：GLIA LLC

  公开号：WO2014152385A2

  公开（公告）日：2014-09-25

  A method for rapid delivery of an active compound to innervate a cranial nerve of a subject. Also provided is a method for treating a disease or condition by topically applying a pharmaceutical composition to the face excluding the palpebral part of the eye, in an amount effective for treating the disease or condition.