(Z)-α-(benzoylhydrazono)phenylacetic acid | 88062-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-α-(benzoylhydrazono)phenylacetic acid
• 英文别名: (2Z)-2-(benzoylhydrazinylidene)-2-phenylacetic acid
• CAS: 88062-46-8
• 化学式: C₁₅H₁₂N₂O₃
• 分子量: 268.272
• InChiKey: IMNJCROFAWJNCV-SSZFMOIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-α-(benzoylhydrazono)phenylacetic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 2,5-diphenyl-1,3,4-oxadiazin-6-one
  参考文献：
  名称：

  Structural characterization of new 2-aryl-5-phenyl-1,3,4-oxadiazin-6-ones and their N-aroylhydrazone precursors

  摘要：

  A series of novel 2,5-disubstituted 1,3,4-oxadiazin-6-ones and their N-aroylhydrazone precursors were synthesized and characterized by NMR and UV-Vis spectroscopy. The electronic properties of 2-aryl-5phenyl-1,3,4-oxadiazin-6-ones are mainly dependent on the 2-aryl substituent and their absorption maxima exhibit a red shift in dichloromethane. Single crystal X-ray diffraction on four acylhydrazones indicated the isolation of isomer with Z configuration of the C=N double bond. Intermolecular interactions through strong H-bonding and C-H...pi contacts serve to link the molecules into a three-dimensional supramolecular network. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2013.11.005
• 作为产物：
  描述：

  苯甲酰肼 、 苯甲酰甲酸 在 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以63%的产率得到(Z)-α-(benzoylhydrazono)phenylacetic acid
  参考文献：
  名称：

  Farina, Carlo; Pifferi, Giorgio; Nasi, Ferdinando, Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 979 - 982

  摘要：

  DOI：

文献信息

• FARINA, C.;PIFFERI, G.;NASI, F.;PINZA, M., J. HETEROCYCL. CHEM., 1983, 20, N 4, 979-982
  作者：FARINA, C.、PIFFERI, G.、NASI, F.、PINZA, M.

  DOI：——

  日期：——
• CHRISTL, M.;LANZENDOERFER, U.;HEGMANN, J.;PETERS, K.;PETERS, E. -M.;SCHNE+, CHEM. BER., 1985, 118, N 7, 2940-2973
  作者：CHRISTL, M.、LANZENDOERFER, U.、HEGMANN, J.、PETERS, K.、PETERS, E. -M.、SCHNE+

  DOI：——

  日期：——
• Methods for the Synthesis of Heteroatom Containing Polycyclic Aromatic Hydrocarbons
  申请人：The Regents of the University of California

  公开号：US20210323987A1

  公开（公告）日：2021-10-21

  Methods for the synthesis of polycyclic aromatic hydrocarbons and synthesis platforms for performing such syntheses are provided. Methods and platforms are provided that allow for the synthesis of aza-polycyclic aromatic hydrocarbons by an expedient ring assembly. Methods and platforms allow for a modular approach to synthesis that provide multiple new C—C bonds in sequential pericyclic reactions, thus giving access to compounds with multiple axes of substitution.