N-[[4-[3-(dimethylamino)propoxy]phenyl]methylene]benezeneethanamine | 65678-27-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[[4-[3-(dimethylamino)propoxy]phenyl]methylene]benezeneethanamine
• 英文别名: N-[[4-[3-(Dimethylamino)propoxy]phenyl]methylene]benzeneethanamine；N,N-dimethyl-3-[4-(2-phenylethyliminomethyl)phenoxy]propan-1-amine
• CAS: 65678-27-5
• 化学式: C₂₀H₂₆N₂O
• 分子量: 310.439
• InChiKey: NEDBBDOJTBAOFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  24.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-[3-(二甲氨基)丙氧基]苯甲醛 生成 N-[[4-[3-(dimethylamino)propoxy]phenyl]methylene]benezeneethanamine
  参考文献：
  名称：

  3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity

  摘要：

  具有以下化学式的化合物具有抗炎活性：##STR1## 其中，R.sub.1为烷基，环烷基或芳基; R.sub.2为二烷基氨基或含氮的杂环基; A.sub.1为饱和键或具有1至4个碳原子的烷基; A.sub.2为具有2至5个碳原子的烷基。

  公开号：

  US04064120A1

文献信息

• Substituted amides and sulfonamides having antiinflammatory activity
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04151354A1

  公开（公告）日：1979-04-24

  Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.

  化合物的化学式为##STR1##其中R.sub.1为烷基、环烷基或芳基；R.sub.2为酰基或磺酰基；R.sub.3为含氮杂环基团；A.sub.1为饱和键或具有1至4个碳原子的烷基链；A.sub.2为具有2至5个碳原子的烷基链；具有抗炎活性。
• Substituted amides having antiinflammatory activity
  申请人：E. R. Squibb and Sons, Inc.

  公开号：US04064125A1

  公开（公告）日：1977-12-20

  Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl; R.sub.3 is alkylamino or dialkylamino; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.

  具有以下化学式的化合物具有抗炎活性：##STR1## 其中R.sub.1是烷基，环烷基或芳基；R.sub.2是酰基；R.sub.3是烷基氨基或二烷基氨基；A.sub.1是饱和键或具有1至4个碳原子的烷基链；A.sub.2是具有2至5个碳原子的烷基链。
• Substituted amides and sulfonamides containing a heterocyclic group
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04122255A1

  公开（公告）日：1978-10-24

  Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.

  具有以下分子式的化合物##STR1##其中R.sub.1是烷基，环烷基或芳基; R.sub.2是酰基或磺酰基; R.sub.3是含氮杂环基团; A.sub.1是饱和键或具有1至4个碳原子的烷基; A.sub.2是具有2至5个碳原子的烷基; 具有抗炎活性。
• Substituted sulfonamides having antiinflammatory activity
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04127606A1

  公开（公告）日：1978-11-28

  Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is sulfonyl; R.sub.3 is alkylamino or dialkylamino; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.

  具有以下化学式的化合物##STR1##其中R.sub.1是烷基，环烷基或芳基; R.sub.2是磺酰基; R.sub.3是烷基氨基或二烷基氨基; A.sub.1是饱和键或具有1至4个碳原子的烷基链; A.sub.2是具有2至5个碳原子的烷基链; 具有抗炎活性。
• 3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04064120A1

  公开（公告）日：1977-12-20

  Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is dialkylamino or a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.

  具有以下化学式的化合物具有抗炎活性：##STR1## 其中，R.sub.1为烷基，环烷基或芳基; R.sub.2为二烷基氨基或含氮的杂环基; A.sub.1为饱和键或具有1至4个碳原子的烷基; A.sub.2为具有2至5个碳原子的烷基。