N-羰基厄他培南二聚物杂质 | 1199797-43-7

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 中文名称: N-羰基厄他培南二聚物杂质
• 英文名称: Ertapenem N-Carbonyl Dimer Impurity
• 英文别名: (4R,5S,6S)-3-[(3S,5S)-5-[[3-[(2S,4S)-4-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl]-2-[(3-carboxyphenyl)carbamoyl]pyrrolidine-1-carbonyl]phenyl]carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• CAS: 1199797-43-7
• 化学式: C₄₄H₄₈N₆O₁₃S₂
• 分子量: 933.0
• InChiKey: QPSFVRZTQQVRAQ-BNCIILEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  65
• 可旋转键数：
  14
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  334
• 氢给体数：
  8
• 氢受体数：
  16

文献信息

• Polymorphic forms of ertapenem monosodium salt and process for it's preparation
  申请人：Ranbaxy Laboratories Limited

  公开号：EP2505190A1

  公开（公告）日：2012-10-03

  The invention relates to a polymorphic form of ertapenem monosodium (Formula I) as Form D and its preparation. Polymorphic form D is characterized by having an XRPD pattern showing 2 theta values at 4.44±0.2, 5.26±0.2, 7.44±0.2, 8.12±0.2, 10.98±0.2, 12.74±0.2, 19.28±0.2, 22.93±0.2, 23.51±0.2, 25.07±0.2 and 30.15 ±0.2.

  本发明涉及一种多晶型的厄他培南单钠（式 I），即形式 D 及其制备方法。 多晶型 D 的特征是其 XRPD 图谱显示 2θ 值为 4.44±0.2、5.26±0.2、7.44±0.2、8.12±0.2、10.98±0.2、12.74±0.2、19.28±0.2、22.93±0.2、23.51±0.2、25.07±0.2 和 30.15±0.2。
• Lyophilized Carbapenem antibiotic composition
  申请人：Ranbaxy Laboratories Limited

  公开号：EP2505191A1

  公开（公告）日：2012-10-03

  The present invention relates to a lyophilized carbapenem antibiotic composition of formula II substantially free of degradation impurities, and its process of preparation.

  本发明涉及一种基本上不含降解杂质的式 II 的冻干碳青霉烯类抗生素组合物及其制备工艺。
• PROCESS FOR PREPARING A CARBAPENEM ANTIBIOTIC COMPOSITION
  申请人：George Vinod

  公开号：US20110172201A1

  公开（公告）日：2011-07-14

  The present invention relates to a process for preparing a carbapenem antibiotic composition. The present invention further relates to a carbapenem antibiotic composition substantially free of degradation impurities. The present invention further relates to a polymorphic form of ertapenem mono sodium designated as Form D and its preparation.
• [EN] PROCESS FOR PREPARING A CARBAPENEM ANTIBIOTIC COMPOSITION<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UNE COMPOSITION ANTIBIOTIQUE À BASE DE CARBAPÉNÈME
  申请人：RANBAXY LAB LTD

  公开号：WO2009150630A2

  公开（公告）日：2009-12-17

  The present invention relates to a process for preparing a carbapenem antibiotic composition, Formula (II). The present invention further relates to a carbapenem antibiotic composition substantially free of degradation impurities. The present invention further relates to a polymorphic form of ertapenem monosodium designated as Form D and its preparation.