(4-Azidophenyl)methyl formate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Azidophenyl)methyl formate
• 英文别名: (4-azidophenyl)methyl formate
• 化学式: C8H7N3O2
• 分子量: 177.16
• InChiKey: ZTEUHVDIUSDTSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] TUBULYSIN DERIVATIVES AND METHODS FOR PREPARING THE SAME<br/>[FR] DÉRIVÉS DE TUBULYSINE ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：UNIV GRONINGEN

  公开号：WO2020022892A1

  公开（公告）日：2020-01-30

  The invention relates to novel means and methods for the synthesis of tubulysin and derivatives thereof, which find their use e.g. as cytotoxic agents in targeted drug delivery. Provided is a method for preparing a tubulysin derivative, comprising reacting compounds A, B and C in a 3- component Passerini reaction, wherein compound A is a carboxylic acid according to the general formula (A); wherein compound B is an aldehyde according to the general formula (B); and wherein compound C is an isocyanide according to the general formula (C).

  该发明涉及一种用于合成管肽素及其衍生物的新手段和方法，这些管肽素及其衍生物可用作靶向药物传递中的细胞毒性剂。提供了一种制备管肽素衍生物的方法，包括在三组分Passerini反应中使化合物A、B和C反应，其中化合物A是符合通用式(A)的羧酸；化合物B是符合通用式(B)的醛；化合物C是符合通用式(C)的异氰酸酯。
• Separation material comprising phosphoryl choline derivatives
  申请人：Pentracor GmbH

  公开号：EP2957563A1

  公开（公告）日：2015-12-23

  The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material, which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also claimed is a device containing a column that comprises separation material made from formula (I) wherein L is a linker as defined in the claims; X is selected from: -SH, -NHR3, -C=CH, -CH=CH2, -N3, -CHO. Also claimed is a separation material of general formula (II): wherein A is a solid support; Y is a group obtainable from the reactive group X.

  本发明提供了一般式（I）的磷酸胆碱衍生物，适合固定在固体支架上，以提供分离材料，其具有与蛋白质高亲和力和高特异性结合的能力，更具体地结合到C-反应蛋白和抗磷酸胆碱抗体。该分离材料在从患者的生物液中外体清除C-反应蛋白和抗磷酸胆碱抗体，以预防和/或治疗免疫功能障碍和心血管疾病方面特别有用。还声明了一种包含由公式（I）制成的分离材料的柱子的装置，其中L是如权利要求中定义的连接剂;X选自：-SH，-NHR3，-C = CH，-CH = CH2，-N3，-CHO。还声明了一种一般式（II）的分离材料：其中A是固体支架; Y是从反应基团X获得的基团。
• METHOD FOR SYNTHESIZING PEPTIDES IN CELL-FREE TRANSLATION SYSTEM
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20200040372A1

  公开（公告）日：2020-02-06

  An objective of the present invention is to provide methods of synthesizing peptides containing structurally diverse amino acids using cell-free translation systems, which can accomplish excellent translational efficiency as compared to conventional techniques (the conventional techniques being methods which involve preparing aminoacyl-tRNAs which do not have protecting groups outside the translation systems without using ARS, and then adding the prepared aminoacyl-tRNAs into translation systems). In the present invention, it was found that amino acid-containing peptides can be synthesized efficiently by protecting an amino acid linked to tRNA with an appropriate protecting group, and then performing the step of deprotecting the protecting group of the amino acid linked to tRNA and the step of peptide translation from a template nucleic acid in a cell-free translation system in parallel.

  本发明的一个目标是提供使用无细胞翻译系统合成含有结构多样的氨基酸的肽的方法，这些方法可以实现与传统技术相比出色的翻译效率（传统技术是指涉及在翻译系统外部准备没有保护基的氨酰-tRNA而不使用ARS的方法，然后将准备好的氨酰-tRNA添加到翻译系统中）。在本发明中，发现通过用适当的保护基保护与tRNA连接的氨基酸，然后并行进行去保护氨基酸与tRNA连接的保护基的步骤和从模板核酸进行肽翻译的步骤，可以高效地合成含有氨基酸的肽。
• Method for the Preparation of Peptide-Oligonucleotide Conjugates
  申请人：Katzhendler Jehoshua

  公开号：US20080221303A1

  公开（公告）日：2008-09-11

  The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

  本发明涉及肽-寡核苷酸共轭物（POC）的合成。更具体地说，本发明涉及一种新颖的肽-寡核苷酸共轭物的制备方法，可以在固相支持下在温和条件下进行，可以手动或通过合成器进行，可以用于合成肽和寡核苷酸的交替序列，并适用于从交替肽和寡核苷酸块构建的各种肽-寡核苷酸共轭物的合成。
• Detection Assays and Use Thereof
  申请人：Haff Lawrence A.

  公开号：US20100159446A1

  公开（公告）日：2010-06-24

  The invention provides compositions and methods for the detection and/or quantification of biological targets (e.g., nucleic acids and proteins) by the nucleic acid-templated creation of one or more reaction products, for example, epitopes, enzyme substrates, enzyme activators, and ligands. The reaction products can be detected and/or quantitated after signal amplification using an amplification system.

  本发明提供了一种通过核酸模板创建一个或多个反应产物（例如表位、酶底物、酶活化剂和配体）来检测和/或定量生物靶标（例如核酸和蛋白质）的组合物和方法。在使用放大系统进行信号放大后，可以检测和/或定量反应产物。