2-chloro-4-(2-morpholinoethoxy) aniline | 1018895-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-chloro-4-(2-morpholinoethoxy) aniline
• 英文别名: 2-Chloro-4-(2 morpholinoethoxy)aniline；2-chloro-4-(2-morpholin-4-ylethoxy)aniline
• CAS: 1018895-17-4
• 化学式: C₁₂H₁₇ClN₂O₂
• mdl: MFCD17934698
• 分子量: 256.732
• InChiKey: JQIQAPGNEHFIGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-chloro-4-(2-morpholinoethoxy) aniline 、 5-chloro-7-(4H-1,2,4-triazol-3-yl)benzo[c][2,6]naphthyridine 以 N-甲基吡咯烷酮 为溶剂， 生成 N-[2-chloro-4-(2-morpholin-4-ylethoxy)phenyl]-7-(1H-1,2,4-triazol-5-yl)benzo[c][2,6]naphthyridin-5-amine
  参考文献：
  名称：

  7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity

  摘要：

  A novel class of pan-Pim kinase inhibitors was designed by modifying the CK2 inhibitor CX-4945. Introduction of a triazole or secondary amide functionality on the C-7 position and 2'-halogenoanilines on C-5 resulted in potent inhibitors of the Pim-1 and Pim-2 isoforms, with many analogs active at single digit nanomolar concentrations. The molecules inhibited the phosphorylation at Serine 112 of the apoptosis effector BAD, and had potent antiproliferative effects on the AML cell line MV-4-11 ( IC50 < 30 nM). This work delivers an excellent lead-optimization platform for Pim targeting anticancer therapies. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.059
• 作为产物：
  描述：

  2-methyl-4-(3-morpholinopropoxy)aniline 、 4-(2-(3-chloro-4-nitrophenoxy)ethyl)morpholine 、 甲酸铵 在 铁粉 2-chloro-4-(2-morpholinoethoxy) aniline 作用下， 以 氧,甲苯 为溶剂， 以to give 2-chloro-4-(2 morpholinoethoxy)aniline in 87% yield的产率得到2-chloro-4-(2-morpholinoethoxy) aniline
  参考文献：
  名称：

  JAK-2 modulators and methods of use

  摘要：

  本发明涉及蛋白酪氨酸激酶及其抑制剂领域。具体来说，本发明涉及JAK-2的抑制剂、用于抑制JAK-2的化合物的制药组合物、在细胞中抑制JAK-2的方法，包括将需要抑制JAK-2的细胞与本发明的化合物或制药组合物中含有的化合物接触。本发明还包括治疗涉及JAK-2的疾病或病症的方法，包括向患者投与本发明的化合物组成的制药组合物。

  公开号：

  US08088767B2
• 作为试剂：
  描述：

  2-methyl-4-(3-morpholinopropoxy)aniline 、 4-(2-(3-chloro-4-nitrophenoxy)ethyl)morpholine 、 甲酸铵 在 铁粉 2-chloro-4-(2-morpholinoethoxy) aniline 作用下， 以 氧,甲苯 为溶剂， 以to give 2-chloro-4-(2 morpholinoethoxy)aniline in 87% yield的产率得到2-chloro-4-(2-morpholinoethoxy) aniline
  参考文献：
  名称：

  JAK-2 Modulators and Methods of Use

  摘要：

  本发明涉及蛋白酪氨酸激酶及其抑制剂领域。具体而言，本发明涉及JAK-2的抑制剂，以及用于抑制JAK-2的化合物的制药组合物，包括通过将含有本发明化合物的化合物或制药组合物与需要抑制JAK-2的细胞接触来抑制JAK-2的细胞方法。本发明还包括治疗涉及JAK-2的疾病或病状的方法，包括向患者施用包含本发明化合物的制药组合物。

  公开号：

  US20100136136A1

文献信息

• PROTEIN KINASE MODULATORS
  申请人：CHUA Peter C.

  公开号：US20090239859A1

  公开（公告）日：2009-09-24

  The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.

  该发明部分涉及具有特定生物活性的分子，包括但不限于抑制细胞增殖、调节蛋白激酶活性和调节聚合酶活性。该发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶（Flt）活性。该发明还涉及使用这些分子的方法。
• Discovery of novel VEGFR-2 inhibitors. Part II: Biphenyl urea incorporated with salicylaldoxime
  作者：Hongping Gao、Ping Su、Yaling Shi、Xiuxiu Shen、Yanmin Zhang、Jinyun Dong、Jie Zhang

  DOI：10.1016/j.ejmech.2014.11.032

  日期：2015.1

  A series of novel VEGFR-2 inhibitors containing oxime as hinge binding fragment were described. A strategy of pseudo six-membered ring formed through intramolecular hydrogen bond was employed to mimic the planar quinazoline. The oxime group was firstly introduced to interact with hinge region of VEGFR-2. Most of compounds tested showed moderate to high VEGFR-2 inhibitory activity. In particular, 121, 12p and 12y exhibited significant enzymatic inhibitory activity as well as potent antiproliferative activity against cancer cells. Molecular docking suggested that the salicylaldoxime formed two hydrogen bonds with hinge region. These biphenylureas could serve as promising lead compounds for developing novel anticancer agents. (C) 2014 Elsevier Masson SAS. All rights reserved.
• IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS
  申请人：Exelixis, Inc.

  公开号：EP2061768A2

  公开（公告）日：2009-05-27
• US8088767B2
  申请人：——

  公开号：US8088767B2

  公开（公告）日：2012-01-03
• US8168651B2
  申请人：——

  公开号：US8168651B2

  公开（公告）日：2012-05-01