Gly-GHB-tBu

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly-GHB-tBu
• 英文别名: Tert-butyl 4-(2-aminoacetyl)oxybutanoate；tert-butyl 4-(2-aminoacetyl)oxybutanoate
• 化学式: C₁₀H₁₉NO₄
• 分子量: 217.265
• InChiKey: ANALWUMNPXBWLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 以100 %的产率得到Gly-GHB-tBu
  参考文献：
  名称：

  [EN] GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
  [FR] COMPOSÉS D'ADMINISTRATION DE GAMMA-HYDROXYBUTYRATE ET LEURS PROCÉDÉS DE PRÉPARATION ET MÉTHODES D'UTILISATION

  摘要：

  Disclosed are compounds comprising chemically modified gamma-hydroxybutyrate (GHB) having the structure of Formula I, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment are also disclosed.

  公开号：

  WO2023205233A1

文献信息

• [EN] GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM<br/>[FR] COMPOSÉS D'ADMINISTRATION DE GAMMA-HYDROXYBUTYRATE ET LEURS PROCÉDÉS DE PRÉPARATION ET MÉTHODES D'UTILISATION
  申请人：[en]ZEVRA THERAPEUTICS, INC.

  公开号：WO2023205233A1

  公开（公告）日：2023-10-26

  Disclosed are compounds comprising chemically modified gamma-hydroxybutyrate (GHB) having the structure of Formula I, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment are also disclosed.