4-nitrobenzaldehyde N-methylthiosemicarbazone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitrobenzaldehyde N-methylthiosemicarbazone
• 英文别名: 1-methyl-3-[(E)-(4-nitrophenyl)methylideneamino]thiourea
• 化学式: C₉H₁₀N₄O₂S
• 分子量: 238.27
• InChiKey: SVOLUGVHMCTSGL-IZZDOVSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-nitrobenzaldehyde N-methylthiosemicarbazone 、 马来酸酐 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 以26%的产率得到(3-Methyl-2-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazono}-4-oxo-thiazolidin-5-yl)-acetic acid
  参考文献：
  名称：

  Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity

  摘要：

  Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.048
• 作为产物：
  描述：

  对硝基苯甲醛 、 4-甲基氨基硫脲 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 以87%的产率得到4-nitrobenzaldehyde N-methylthiosemicarbazone
  参考文献：
  名称：

  Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity

  摘要：

  Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.048

文献信息

• OPTICAL FILM
  申请人：SK Innovation Co., Ltd.

  公开号：EP2722356A2

  公开（公告）日：2014-04-23

  The present invention relates to a cellulose acetate film for optical compensation and a retardation enhancer used therein, and relates to a cellulose acetate film which has a high retardation value in the thickness direction (Rth).

  本发明涉及一种用于光学补偿的醋酸纤维素薄膜及其所用的缓凝增强剂，并涉及一种在厚度方向上具有高缓凝值（Rth）的醋酸纤维素薄膜。
• Optical Film
  申请人：Kim Won Yeob

  公开号：US20140116293A1

  公开（公告）日：2014-05-01

  The present invention relates to a cellulose acetate film for optical compensation and a retardation enhancer used therein, and relates to a cellulose acetate film which has a high retardation value in the thickness direction (Rth).
• Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity
  作者：Rômulo P. Tenório、Cristiane S. Carvalho、Carla S. Pessanha、José G. de Lima、Antônio R. de Faria、Antônio J. Alves、Edésio J.T. de Melo、Alexandre J.S. Góes

  DOI：10.1016/j.bmcl.2005.03.048

  日期：2005.5

  Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii. (c) 2005 Elsevier Ltd. All rights reserved.