N-苄基-4,5-二氢噻唑-2-胺 | 13578-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-苄基-4,5-二氢噻唑-2-胺
• 英文名称: benzyl-(4,5-dihydro-thiazol-2-yl)-amine
• 英文别名: N-benzyl-4,5-dihydro-1,3-thiazol-2-amine
• CAS: 13578-57-9
• 化学式: C₁₀H₁₂N₂S
• mdl: MFCD01411547
• 分子量: 192.285
• InChiKey: GANOLKRMSPPWQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-苄基-4,5-二氢噻唑-2-胺 生成 1,1'-(Dithiodiethylen)-2,2'-bis-(3-benzyl-thioharnstoff)
  参考文献：
  名称：

  2-Amino-2-thiazoline. IV. Ring-opening of 2-amino-2-thiazolines and 2-amino-2-selenazoline with hydrogen sulfide to form thiourea derivatives

  摘要：

  DOI：

  10.1021/jo01266a102
• 作为产物：
  描述：

  苄基二硫代氨基甲酸三乙胺盐 在 盐酸 、 sodium carbonate 、 三乙胺 作用下， 以 氯仿 、 丙酮 为溶剂， 反应 30.0h， 生成 N-苄基-4,5-二氢噻唑-2-胺
  参考文献：
  名称：

  Aminothiazines et aminothiazoles analogues ouverts du lévamisole: synthèse et approche du mode d'action nématicide

  摘要：

  DOI：

  10.1016/0223-5234(89)90011-1

文献信息

• [EN] PYRROLIN-2-YLAMINO COMPOUNDS FOR COMBATING ANIMAL PESTS<br/>[FR] COMPOSÉS PYRROLIN-2-YLAMINO DESTINÉS À COMBATTRE LES ANIMAUX NUISIBLES
  申请人：BASF SE

  公开号：WO2010029069A1

  公开（公告）日：2010-03-18

  The present invention relates to pyrrolin-2-ylamino compounds for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to plant propagation material and to an agricultural composition comprising said compounds. The invention also relates to a method for treating or protecting an animal from infestation or infection by parasites by using said compounds. Formula (I) wherein n is 0, 1, 2, 3, 4 or 5; m is 0, 1, 2, 3, 4 or 5; R1, R2 are each independently selected from the group consisting of: halogen, CN, N3, NO2, C1-C6-alkyl, C2-C6-alkenyl and C2-C6-alkynyl, where the last 3 radicals mentioned may be partly or completely halogenated and/or may carry any combination of 1, 2 or 3 radicals R#, etc.; R3 and R4 are selected each independently of one another from hydrogen, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, wherein the last 3 radicals mentioned may be partly or completely halogenated and/or may carry any combination of 1, 2 or 3 radicals selected independently of one another from the group consisting of CN, NO2, -ORb, NRcRd, -SRe, -C(=O)Ra and -C(=O)ORb, etc.; A is a radical of the formulae A.1 or A.2, wherein * indicates the point of attachment to the remaining part of the compound; R5a, R5b, R5c, R5d, R5e and R5f are selected independently from one another from hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino, di(C1-C6-alkyl)amino, C3-C6- cycloalkyl and Ar2, etc.; R6 and R7 are selected each independently from one another from hydrogen, CN, NO2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, saturated or partially unsaturated 5-, 6- or 7-membered heterocyclic radicals, Ar3, etc.

  本发明涉及用于对抗动物害虫的吡咯啉-2-基氨基化合物。该发明还涉及一种通过使用这些化合物来控制动物害虫的方法，以及包括所述化合物的植物繁殖材料和农业组合物。该发明还涉及一种通过使用这些化合物来治疗或保护动物免受寄生虫感染的方法。其中，公式（I）中n为0、1、2、3、4或5；m为0、1、2、3、4或5；R1、R2分别独立选择自卤素、CN、N3、NO2、C1-C6-烷基、C2-C6-烯基和C2-C6-炔基等的基团；R3和R4各自独立选择自氢、卤素、C1-C6-烷基、C2-C6-烯基、C2-C6-炔基等的基团，其中最后提到的3个基团可能部分或完全卤代，和/或可能携带任意组合的1、2或3个基团R#等；A是公式A.1或A.2的基团，其中*表示与化合物其余部分的连接点；R5a、R5b、R5c、R5d、R5e和R5f各自独立选择自氢、卤素、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基、双（C1-C6-烷基）氨基、C3-C6-环烷基和Ar2等的基团；R6和R7各自独立选择自氢、CN、 、C1-C6-烷基、C2-C6-烯基、C2-C6-炔基、C3-C8-环烷基、饱和或部分不饱和的5、6或7-成员杂环基团、Ar3等的基团。
• [EN] 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS<br/>[FR] COMPOSÉS 1-(AZOLIN-2-YL)AMINO-1,2-DIPHÉNYLÉTHANE POUR LUTTER CONTRE LES ANIMAUX NUISIBLES
  申请人：BASF SE

  公开号：WO2009004032A1

  公开（公告）日：2009-01-08

  The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and to their salts which are useful for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds, wherein A is a radical of formulae A.1 or A.2 wherein # denotes the bond to the remaining compound of formula I, X is selected from O, S and NRx, R1 is selected from the group consisting of -ORA, -NRB1RB2, -C(=O)-RC, -C(=O)-ORD, -C(=O)-SRE, -C(=O)-NRB1RB2', -C(=S)-RC', -C(=S)-ORD', -C(=S)-SRE', -C(=S)-NRB1RB2, -C(=NR1a)-RC', -C(=NR1b)-ORD', -C(=NR1c)-SRE', -C(=NR1d)-NRB1RB2, -S(=O)-RF, -S(=O)2-RG, -S(=O)2-NRB1RB2', -P(=O)RH1RH2, -P(=S)RH1RH2, -B-C(=O)-RI, -B-O-C(=O)-RI, -B-S-C(=O)-RI, -B-N(RJ)-C(=O)-RK, -B-C(=S)-RK, -B-O-C(=S)-RK, -B-S-C(=S)-RK, -B-N(RJ)-C(=S)-RK, C1-C8-alkenyl, C1-C8-alkynyl, C3-C8-cycloalkyl, which is unsubstituted or may carry 1 to 4 substituents R1e, naphthyl, which is unsubstituted or may carry 1 to 4 substituents R1f, a saturated or partially unsaturated heterocycle, which is unsubstituted or may carry 1 to 4 substituents R1g, hetaryl, which is unsubstituted or may carry 1 to 4 substituents R1h, and C1-C6-alkyl, which carries a radical selected from the group consisting of -NR1iR1j, C1-C4-alkoxycarbonyl, C3-C8-cycloalkyl, aryl, aryloxy, arylthio, heterocyclyl, heterocyclyloxy and heterocyclylthio, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, halogen, OH, SH, NH2, SO3H, COOH, cyano, nitro, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino etc.

  本发明涉及公式I的1-(咪唑啉-2-基)氨基-1,2-二苯乙烷化合物及其盐，用于防治动物害虫。本发明还涉及使用这些化合物控制动物害虫的方法，种子以及包含所述化合物的农业和兽医组合物，其中A是公式A.1或A.2的基团，其中#表示与公式I的其余化合物的键合，X从O、S和NRx中选择，R1从由-ORA、-NRB1RB2、-C（=O）-RC、-C（=O）-ORD、-C（=O）-SRE、-C（=O）-NRB1RB2'、-C（=S）-RC'、-C（=S）-ORD'、-C（=S）-SRE'、-C（=S）-NRB1RB2、-C（=NR1a）-RC'、-C（=NR1b）-ORD'、-C（=NR1c）-SRE'、-C（=NR1d）-NRB1RB2、-S（=O）-RF、-S（=O）2-RG、-S（=O）2-NRB1RB2'、-P（=O）RH1RH2、-P（=S）RH1RH2、-B-C（=O）-RI、-B-O-C（=O）-RI、-B-S-C（=O）-RI、-B-N（RJ）-C（=O）-RK、-B-C（=S）-RK、-B-O-C（=S）-RK、-B-S-C（=S）-RK、-B-N（RJ）-C（=S）-RK、C1-C8-烯丙基、C1-C8-炔基、C3-C8-环烷基，未取代或可携带1至4个取代基R1e，萘基，未取代或可携带1至4个取代基R1f，饱和或部分不饱和的杂环，未取代或可携带1至4个取代基R1g，杂芳基，未取代或可携带1至4个取代基R1h，以及C1-C6-烷基，携带从由-NR1iR1j、C1-C4-烷氧羰基、C3-C8-环烷基、芳基、芳氧基、芳硫基、杂环基、杂环氧基和杂环硫基选择的基团，R2、R3、R4、R5、R6和R7各自独立地为氢、卤素、OH、SH、NH2、SO3H、COOH、氰基、硝基、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基等。
• Insecticidal Derivates of Substituted Phosphorylated Phenylalkyl Iminooxazolines and Iminothiazolines
  申请人：Bayer CropScience AG

  公开号：EP2096114A1

  公开（公告）日：2009-09-02

  The present invention relates to novel substituted phosphorylated phenalkyliminooxazolines and phenalkyliminothiazolines, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.

  本发明涉及一种新型取代磷酸化苯基脂肪基亚唑啉和苯基脂肪基亚噻唑啉，其制备方法以及它们在控制动物害虫，特别是节肢动物，特别是昆虫方面的用途。
• Insecticidal Substituted Benzylamino Heterocyclic and Heteroaryl Derivatives
  申请人：Dixson John A.

  公开号：US20090036306A1

  公开（公告）日：2009-02-05

  Certain substituted benzylamino heterocyclic and heteroaryl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (1): wherein R, R1, R2, R3, and R4 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (1), and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  某些取代苯基氨基的杂环和杂环芳基衍生物具有出乎意料的杀虫和杀螨活性。这些化合物由公式(1)表示:其中R、R1、R2、R3和R4在此完整描述。此外，还公开了包含公式(1)中至少一种化合物的杀虫有效量的组合物，以及可选地，至少一种附加化合物的有效量，与至少一种杀虫兼容载体的组合物;以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。
• 1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests
  申请人：Kordes Markus

  公开号：US20100280078A1

  公开（公告）日：2010-11-04

  The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and to their salts which are useful for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds. wherein A is a radical of formulae A.1 or A.2 wherein # denotes the bond to the remaining compound of formula I, X is selected from O, S and NR X , R 1 is selected from the group consisting of —OR A , —NR B1 R B2 , C(═O)—R C , —C(═O)—OR D , —C(═O)—SR E , —C(═O)—NR B1 R B2 ′, —C(═S)—R C ′, —C(═S)—OR D ′, —C(═S)—SR E ′, —C(═S)—NR B1 R B2 , —C(═NR 1a )—R C ′, —C(═NR 1b )—OR D ′, —C(═NR 1c )—SR E ′, —C(═NR 1d )—NR B1 R B2 , —S(═O)—R F , —S(═O) 2 —R G , —S(═O) 2 —NR B1 R B2 ′, —P(═O)R H1 R H2 , —P(═S)R H1 R H2 , —B—C(═O)—R I , —B—O—C(═O)—R I , —B—S—C(═O)—R I , —B—N(R J )—C(═O)—R K , —B—C(═S)—R K , —B—O—C(═S)—R K , —B—S—C(═S)—R K , —B—N(R J )—C(═S)—R K , C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 3 -C 8 -cycloalkyl, which is unsubstituted or may carry 1 to 4 substituents R 1e , naphthyl, which is unsubstituted or may carry 1 to 4 substituents R 1f , a saturated or partially unsaturated heterocycle, which is unsubstituted or may carry 1 to 4 substituents R 1g , hetaryl, which is unsubstituted or may carry 1 to 4 substituents R 1h , and C 1 -C 6 -alkyl, which carries a radical selected from the group consisting of —NR 1i R 1j , C 1 -C 4 -alkoxycarbonyl, C 3 -C 8 -cycloalkyl, aryl, aryloxy, arylthio, heterocyclyl, heterocyclyloxy and heterocyclylthio, R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each independently hydrogen, halogen, OH, SH, NH 2 , SO 3 H, COOH, cyano, nitro, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino etc.

  本发明涉及公式I的1-(噁唑-2-基)氨基-1,2-二苯乙烷化合物及其盐，用于对抗动物害虫。本发明还涉及使用这些化合物控制动物害虫的方法，种子以及包括所述化合物的农业和兽医组合物。其中A是公式A.1或A.2的基团，#表示与公式I的其余化合物的键，X从O、S和NRX中选择，R1从—ORA、—NRB1RB2、C(═O)—RC、—C(═O)—ORD、—C(═O)—SRE、—C(═O)—NRB1RB2′、—C(═S)—RC′、—C(═S)—ORD′、—C(═S)—SRE′、—C(═S)—NRB1RB2、—C(═NR1a)—RC′、—C(═NR1b)—ORD′、—C(═NR1c)—SRE′、—C(═NR1d)—NRB1RB2、—S(═O)—RF、—S(═O)2—RG、—S(═O)2—NRB1RB2′、—P(═O)RH1RH2、—P(═S)RH1RH2、—B—C(═O)—RI、—B—O—C(═O)—RI、—B—S—C(═O)—RI、—B—N(RJ)—C(═O)—RK、—B—C(═S)—RK、—B—O—C(═S)—RK、—B—S—C(═S)—RK、—B—N(RJ)—C(═S)—RK、C1-C8-烯丙基、C1-C8-炔基、C3-C8-环烷基，未取代或可携带1至4个取代基R1e，萘基，未取代或可携带1至4个取代基R1f，饱和或部分不饱和的杂环，未取代或可携带1至4个取代基R1g，杂芳基，未取代或可携带1至4个取代基R1h，以及携带从—NR1iR1j、C1-C4-烷氧羰基、C3-C8-环烷基、芳基、芳氧基、芳硫基、杂环基、杂环氧基和杂环硫基中选择的基团的C1-C6-烷基，R2、R3、R4、R5、R6和R7各自独立地为氢、卤素、OH、SH、NH2、SO3H、COOH、氰基、硝基、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基等。