Hydroxyaminopimelic acid | 77572-83-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Hydroxyaminopimelic acid
• 英文别名: 2-amino-6-hydroxyheptanedioic acid
• CAS: 77572-83-9
• 化学式: C₇H₁₃NO₅
• 分子量: 191.18
• InChiKey: SWHKKAYZRUACJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHODS OF PRODUCING 6-CARBON CHEMICALS USING 2,6-DIAMINOPIMELATE AS PRECURSOR TO 2-AMINOPIMELATE
  申请人：INVISTA North America S.á r.l.

  公开号：US20150361462A1

  公开（公告）日：2015-12-17

  This document describes biochemical pathways for producing 2-aminopimelate from 2,6-diaminopimelate, and methods for converting 2-aminopimelate to one or more of adipic acid, adipate semialdehyde, caprolactam, 6-aminohexanoic acid, 6-hexanoic acid, hexamethylenediamine, or 1,6-hexanediol by decarboxylating 2-aminopimelate into a six carbon chain aliphatic backbone and enzymatically forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in the backbone.

  本文件描述了从2,6-二氨基戊二酸生产2-氨基戊二酸的生化途径，并且提供了将2-氨基戊二酸转化为脂肪二酸、脂肪酸半醛、己内酰胺、6-氨基己酸、6-己酸、六亚甲基二胺或1,6-己二醇的方法，通过将2-氨基戊二酸脱羧成为六碳链脂肪骨架，并在骨架中酶催化形成一个或两个端基官能团，包括羧基、氨基或羟基。
• METHODS AND MICROORGANISMS FOR THE BIOLOGICAL SYNTHESIS OF (S)-2-AMINO-6-HYDROXYPIMELATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROATE
  申请人：Bioamber Inc.

  公开号：EP2888356A1

  公开（公告）日：2015-07-01
• Methods and Microorganisms for the Biological Synthesis of (S) -2-amino-6-hydroxypimelate, Hexamethylenediamine and 6-aminocaproate
  申请人：BioAmber Inc.

  公开号：US20150203879A1

  公开（公告）日：2015-07-23

  A chemical having the formula (S) 2-amino-6-hydroxypimelate. (S)-2-amino-6-hydroxypimelate can be made using a method comprising culturing a cell comprising an exogenous nucleic acid sequence encoding an enzyme that catalyzes the substrate to product conversion of (S)-2-amino-6-oxopimelate to (S)-2-amino-6-hydroxypimelate and separating the (S)-2-amino-6-hydroxypimelate. The cell may be a recombinant microorganism for producing aminocaproic acid or hexamethylenediamine from (S)-2-amino-6-hydroxypimelate comprising at least one exogenous nucleic acid sequence that expresses at least one polypeptide with substrate preference for homolysine, and amino acid decarboxylase with substrate preference for alpha-aminopimelate.
• US8404465B2
  申请人：——

  公开号：US8404465B2

  公开（公告）日：2013-03-26
• US9745607B2
  申请人：——

  公开号：US9745607B2

  公开（公告）日：2017-08-29