4-(2,2',3,3'-tetramethoxybiphenyl-6-yl)acetyl morpholine | 197841-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,2',3,3'-tetramethoxybiphenyl-6-yl)acetyl morpholine
• 英文别名: 2-[2-(2,3-Dimethoxyphenyl)-3,4-dimethoxyphenyl]-1-morpholin-4-ylethanone
• CAS: 197841-17-1
• 化学式: C₂₂H₂₇NO₆
• 分子量: 401.459
• InChiKey: AEMXJDGQRLXDME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  66.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(2,2',3,3'-tetramethoxybiphenyl-6-yl)acetyl morpholine 在 三氯氧磷 作用下， 以 甲苯 、 苯 为溶剂， 反应 1.0h， 以42%的产率得到4-[10-(3,4,5,6-tetramethoxy)phenanthryl]morpholine
  参考文献：
  名称：

  Sequential bicyclization of biphenyl acetamides promoted by (COCl)2/SnCl4. Total synthesis of 4,5-dioxoaporphines

  摘要：

  The reaction of biphenyl acetamides with excess of oxalyl chloride/stannyl chloride offers a one pot, high-yield entry to 4,5-dioxoaporphine alkaloids. This strategy has been applied to the synthesis of 4,5-dioxodehydrocorydine starting from 1-iodo-2,3-dimethoxybenzene. The cytotoxicity of tetraoxygenated 4,5-dioxoaporphines has been evaluated. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00923-x
• 作为产物：
  描述：

  4,9,10-Trimethoxy-6H-benzo[c]chromene 在 氢氧化钾 、 lithium aluminium tetrahydride 、 氯化亚砜 、 草酰氯 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 吡啶 、 二氯甲烷 、 氯仿 、 水 、 三乙胺 、 乙腈 、 苯 为溶剂， 反应 109.33h， 生成 4-(2,2',3,3'-tetramethoxybiphenyl-6-yl)acetyl morpholine
  参考文献：
  名称：

  Sequential bicyclization of biphenyl acetamides promoted by (COCl)2/SnCl4. Total synthesis of 4,5-dioxoaporphines

  摘要：

  The reaction of biphenyl acetamides with excess of oxalyl chloride/stannyl chloride offers a one pot, high-yield entry to 4,5-dioxoaporphine alkaloids. This strategy has been applied to the synthesis of 4,5-dioxodehydrocorydine starting from 1-iodo-2,3-dimethoxybenzene. The cytotoxicity of tetraoxygenated 4,5-dioxoaporphines has been evaluated. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00923-x

文献信息

• Sequential bicyclization of biphenyl acetamides promoted by (COCl)2/SnCl4. Total synthesis of 4,5-dioxoaporphines
  作者：Rafael Suau、Juan Manuel López-Romero、Rodrigo Rico

  DOI：10.1016/s0040-4020(97)00923-x

  日期：1997.10

  The reaction of biphenyl acetamides with excess of oxalyl chloride/stannyl chloride offers a one pot, high-yield entry to 4,5-dioxoaporphine alkaloids. This strategy has been applied to the synthesis of 4,5-dioxodehydrocorydine starting from 1-iodo-2,3-dimethoxybenzene. The cytotoxicity of tetraoxygenated 4,5-dioxoaporphines has been evaluated. (C) 1997 Elsevier Science Ltd.