10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one | 1296216-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one
• 英文别名: 10-[4-(trifluoromethyl)phenyl]-2,3,4,10b-tetrahydro-1H-pyrido[1,2-b]isoindol-6-one
• CAS: 1296216-56-2
• 化学式: C₁₉H₁₆F₃NO
• 分子量: 331.337
• InChiKey: FGNCSVAQPOYSKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-6-溴苯甲醛 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 platinum(IV) oxide 、 正丁基锂 、 二(三叔丁基膦)钯 、 氢气 、 caesium carbonate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 正己烷 、 二氯甲烷 为溶剂， -100.0~100.0 ℃ 、101.33 kPa 条件下， 反应 32.75h， 生成 10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one
  参考文献：
  名称：

  Facile and Unified Approach to Skeletally Diverse, Privileged Scaffolds

  摘要：

  A novel strategy has been developed to generate a diverse array of privileged scaffolds from readily available tetrahydropyridine precursors that may be prepared by a multicomponent assembly process followed by a ring-closing metathesis. The functionality embedded in these key Intermediates enables their facile elaboration into more complex structures of biological relevance by a variety of ring-forming processes and refunctionalizations.

  DOI：

  10.1021/ol200709h

文献信息

• Facile and Unified Approach to Skeletally Diverse, Privileged Scaffolds
  作者：James J. Sahn、Justin Y. Su、Stephen F. Martin

  DOI：10.1021/ol200709h

  日期：2011.5.20

  A novel strategy has been developed to generate a diverse array of privileged scaffolds from readily available tetrahydropyridine precursors that may be prepared by a multicomponent assembly process followed by a ring-closing metathesis. The functionality embedded in these key Intermediates enables their facile elaboration into more complex structures of biological relevance by a variety of ring-forming processes and refunctionalizations.