N-苯乙基戊酰胺 | 10264-19-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-苯乙基戊酰胺
• 英文名称: N-(2-phenylethyl)pentanamide
• 英文别名: N-phenethyl-valeramide；N-Phenaethyl-valeramid；N-Phenaethyl-valeramid
• CAS: 10264-19-4
• 化学式: C₁₃H₁₉NO
• mdl: MFCD01358889
• 分子量: 205.3
• InChiKey: RBPXCUDFQLFKPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-苯乙基戊酰胺 在 1,2,3,4-四氢萘 、 phosphorus pentoxide 、 钯 作用下， 生成 1-(正丁基)异喹啉
  参考文献：
  名称：

  Spaeth et al., Chemische Berichte, 1930, vol. 63, p. 134,136

  摘要：

  DOI：
• 作为产物：
  描述：

  戊酰氯 、 2-苯乙胺 以 二氯甲烷 为溶剂， 反应 1.0h， 以78%的产率得到N-苯乙基戊酰胺
  参考文献：
  名称：

  来自耐冷细菌 Chryseo而是多毛菌的挥发物。

  摘要：

  在C. polytrichastri的顶空提取物中已鉴定出70 多种挥发性有机化合物。该提取物富含含氮天然产物，其中许多在结构上源自 2-苯乙胺。几种化合物是新的天然产物，它们的建议结构基于观察到的质谱碎片，并通过参考物质的合成得到证实。

  DOI：

  10.1002/cbic.202000503

文献信息

• Ramoplanin derivatives possessing antibacterial activity
  申请人：Raju G. Bore

  公开号：US20060211603A1

  公开（公告）日：2006-09-21

  Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

  新型拉莫普兰衍生物已被披露。这些拉莫普兰衍生物表现出抗菌活性。由于本发明的化合物对革兰氏阳性细菌表现出强效活性，它们是有用的抗微生物药剂。该化合物的合成方法和使用方法也已被披露。
• HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

  公开号：US20160340328A1

  公开（公告）日：2016-11-24

  Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.

  揭示了具有以下公式的化合物：其中R1、R2和R3如本文所定义，并且制备和使用这些化合物的方法，包括用作BMP1、TLL1和/或TLL2的抑制剂以及用于治疗与BMP1、TLL1和/或TLL2活性相关的疾病。
• A Novel Dehydrazination Reaction. V. The Formation of Various Amides from Aliphatic and Aromatic Carboxylic Acid Hydrazides in the Presence of Chloral
  作者：Tetsuji Kametani、Osamu Umezawa

  DOI：10.1248/cpb.14.369

  日期：——

  In the previous papers the reactions between aromatic, aliphatic and heterocyclic carboxylic acid hydrazides and either chloral or bromal in various alcohols were attempted and respective esters were obtained. In this paper the reactions of aromatic and aliphatic acid hydrazide with chloral in the presence of various amines were examined, leading eventually to reveal the formation of our expected acid amides as are shown in Table I and II. The intermediates in this reaction, 1-benzoyl-2-(2, 2, 2-trichloroethylidene) hydrazine (III : R=C6H5-, X=Cl) was found to form the amides (VI) when heated in amines. This fact indicated that the acid hydrazides converted to their amides through III.

  在前期的论文中，尝试了芳香族、脂肪族及杂环羧酸酰肼与氯醛或溴醛在不同醇类中的反应，并得到了相应的酯类。本文研究了芳香族和脂肪族羧酸酰肼与氯醛在不同胺类存在下的反应，最终揭示了生成我们预期的酸酰胺，如表I和表II所示。在此反应的中间体，即1-苯甲酰基-2-(2,2,2-三氯亚乙基)酰肼(III：R=C6H5-，X=Cl)在加热条件下与胺类反应生成酰胺(VI)。这一事实表明，羧酸酰肼通过中间体III转化为酰胺。
• Direct Synthesis of Imines from Alcohols and Amines with Liberation of H2
  作者：Boopathy Gnanaprakasam、Jing Zhang、David Milstein

  DOI：10.1002/anie.200907018

  日期：2010.2.15

  A clean sweep: Aryl and aliphatic imines can be synthesized directly and efficiently from alcohols and amines under mild, neutral conditions with the liberation of only molecular hydrogen and water (see scheme; R=isopropyl, tert‐butyl). This general, environmentally benign reaction is catalyzed by a de‐aromatized ruthenium PNP pincer complex (0.2 mol %), and can proceed in toluene under an inert atmosphere

  一目了然：在温和的中性条件下，醇和胺可仅由分子氢和水释放（见方案； R =异丙基，叔丁基），可直接有效地由醇和胺合成芳基和脂族亚胺。这种一般的，对环境无害的反应是由脱芳香化的钌PNP钳形配合物（0.2摩尔％）催化的，可以在甲苯中于惰性气氛或空气中进行。
• Copper‐Catalyzed Substrate‐Controlled Carbonylative Synthesis of α‐Keto Amides and Amides from Alkyl Halides
  作者：Fengqian Zhao、Han‐Jun Ai、Xiao‐Feng Wu

  DOI：10.1002/anie.202200062

  日期：2022.4.19

  A copper-catalyzed highly selective double carbonylation of alkyl bromides and amines has been developed. Desired α-keto amides were obtained as the only products. Subsequently, under different conditions, the double and mono-carbonylations of alkyl iodides with amines were also achieved.

  已经开发了一种铜催化的烷基溴和胺的高选择性双羰基化反应。获得所需的α-酮酰胺作为唯一的产物。随后，在不同条件下，还实现了烷基碘与胺的双羰基化和单羰基化。