3-[(5-chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluoro-N'-hydroxybenzenecarboximidamide | 1138333-12-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 3-[(5-chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluoro-N'-hydroxybenzenecarboximidamide
• CAS: 1138333-12-6
• 化学式: C₁₅H₁₀ClF₂N₃O₂S
• 分子量: 369.779
• InChiKey: HTCNXMUIDWXZQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-[(5-chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluoro-N'-hydroxybenzenecarboximidamide 、 甲酸铵 在 钯 乙酸乙酯 、 magnesium sulfate 、 crude residue 、 二甲基亚砜 、 水 、 正戊烷 作用下， 以 溶剂黄146 为溶剂， 反应 3.0h， 以to give 49 mg (33% yield)的产率得到3-[(5-Chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarboximidamide
  参考文献：
  名称：

  Substituted benzamidines as antibacterial agents

  摘要：

  式(I A)或(IB)的化合物具有抗菌活性：其中W是═C(H)—或═N—; R3是式-(Alk1)m-(Z1)p-(Alk2)n-Q的基团，其中m、p和n独立地为0或1，但至少有一个为1，Z1是—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—、—C(═O)—O—，或具有3至6个环原子的可选取代二价单环碳环或杂环基团；或具有5至10个环原子的可选取代二价双环碳环或杂环基团；Alk1和Alk2是可选取代的C1-C6烷基、C2-C6烯基或C2-C6炔基基团，可选择以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—或—N(CH2CH3)—结尾或中断；Q是氢、卤素、腈或羟基，或具有3至6个环原子的可选取代单环碳环或杂环基团；或具有5至10个环原子的可选取代双环碳环或杂环基团；R4和R5是可选取代的取代基；R2、R6和R7独立地为氢或式-(Alk3)x-(Z2)y-(Alk4)z-H的基团，其中x、y和z独立地为0或1，Z2是—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—或—C(═O)—O—；Alk3和Alk4是可选取代的C1-C3烷基、C2-C3烯基或C2-C3炔基基团，可选择以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—或—N(CH2CH3)—结尾或中断。

  公开号：

  US08415383B2
• 作为产物：
  描述：

  3-[(5-Chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarbonitrile 在 盐酸羟胺 、 sodium carbonate 作用下， 以 乙醇 为溶剂， 反应 9.0h， 以73%的产率得到3-[(5-chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluoro-N'-hydroxybenzenecarboximidamide
  参考文献：
  名称：

  SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS

  摘要：

  化合物的结构式（IA）或（IB）具有抗菌活性：其中W为 ═C(H)— 或 ═N—；R3为具有以下结构的基团 -(Alk1)m-(Z1)p-(Alk2)n-Q，其中m、p和n独立地为0或1，但至少m、p和n中的一个为1，Z1为—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—、—C(═O)—O—，或者具有3至6个环原子的可选择取代的一元环碳环或杂环基团；或者具有5至10个环原子的可选择取代的二元环碳环或杂环基团；Alk1和Alk2为可选择取代的C1-C6烷基、C2-C6烯基或C2-C6炔基基团，可能以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、或—N(CH2CH3)—终止或中断；Q为氢、卤素、腈基或羟基，或者具有3至6个环原子的可选择取代的一元环碳环或杂环基团；或者具有5至10个环原子的可选择取代的二元环碳环或杂环基团；R4和R5为可选取代基团；R2、R6和R7独立地为氢或具有以下结构的基团 -(Alk3)x-(Z2)y-(Alk4)z-H，其中x、y和z独立地为0或1，Z2为—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—或—C(═O)—O—；Alk3和Alk4为可选择取代的C1-C3烷基、C2-C3烯基或C2-C3炔基基团，可能以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—或—N(CH2CH3)—终止或中断。

  公开号：

  US20100298388A1

文献信息

• SUBSTITUTED BENZAMIDINES AS ANTIBACTERIAL AGENTS
  申请人：Biota Scientific Management Pty Ltd

  公开号：EP2203219B1

  公开（公告）日：2015-02-25
• US8415383B2
  申请人：——

  公开号：US8415383B2

  公开（公告）日：2013-04-09
• [EN] SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS<br/>[FR] BENAMIDINES SUBSTITUÉES UTILISÉS COMME AGENTS ANTIBACTÉRIENS
  申请人：PROLYSIS LTD

  公开号：WO2009040507A1

  公开（公告）日：2009-04-02

  Compounds of formula (IA) or (IB) have antibacterial activity : wherein W is =C(H)- or =N-; R3 is a radical of formula -(Alk1)m-(Z1)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z1 is -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, -N(CH2CH3)-, -C(-O)-, -0-(C=O)-, -C(=O)-O-, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; AIk1 and AIk2 are optionally substituted C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, Or -N(CH2CH3)-; and Q is hydrogen, halogen, nitrile, or hydroxyl, or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; R4 and R5 are optional substituents; and R2, R6 and R7 are independently hydrogen or a radical of formula -(Alk3)x- (Z2)y-(Alk4)z-H wherein x, y and z are independently 0 or 1, Z2 is -O-, -S-, -S(O)-, -S(O2)-, - NH-, -N(CH3)-, -N(CH2CH3)-, -C(-O)-, -0-(C=O)- or -C(=O)-O-; AIk3 and AIk4 are optionally substituted C1-C3 alkylene, C2-C3 alkenylene, or C2-C3 alkynylene radicals, which may optionally terminate with or be interrupted by -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, or - N(CH2CH3)-.
• SUBSTITUTED BENAMIDINES AS ANTIBACTERIAL AGENTS
  申请人：Haydon David John

  公开号：US20100298388A1

  公开（公告）日：2010-11-25

  Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R 3 is a radical of formula -(Alk 1 ) m -(Z 1 ) p -(Alk 2 ) n -Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1 , Z1 is —O—, —S—, —S(O)—, —S(O 2 )—, —NH—, —N(CH 3 )—, —N(CH 2 CH 3 )—, —C(—O)—, —O—(C═O)—, —C(═O)—O—, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; Alk 1 and Alk 2 are optionally substituted C 1 -C 6 alkylene, C 2 -C 6 alkenylene, or C 2 -C 6 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O 2 )—, —NH—, —N(CH 3 )—, Or —N(CH 2 CH 3 )—; and Q is hydrogen, halogen, nitrile, or hydroxyl, or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; R 4 and R 5 are optional substituents; and R 2 , R 6 and R 7 are independently hydrogen or a radical of formula -(Alk 3 ) x -(Z 2 )y-(Alk 4 ) z -H wherein x, y and z are independently 0 or 1, Z 2 is —O—, —S—, —S(O)—, —S(O 2 )—, —NH—, —N(CH 3 )—, —N(CH 2 CH 3 )—, —C(—O)—, —O—(C═O)— or —C(═O)—O—; Alk 3 and Alk 4 are optionally substituted C 1 -C 3 alkylene, C 2 -C 3 alkenylene, or C 2 -C 3 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O 2 )—, —NH—, —N(CH 3 )—, or —N(CH 2 CH 3 )—.

  化合物的结构式（IA）或（IB）具有抗菌活性：其中W为 ═C(H)— 或 ═N—；R3为具有以下结构的基团 -(Alk1)m-(Z1)p-(Alk2)n-Q，其中m、p和n独立地为0或1，但至少m、p和n中的一个为1，Z1为—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—、—C(═O)—O—，或者具有3至6个环原子的可选择取代的一元环碳环或杂环基团；或者具有5至10个环原子的可选择取代的二元环碳环或杂环基团；Alk1和Alk2为可选择取代的C1-C6烷基、C2-C6烯基或C2-C6炔基基团，可能以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、或—N(CH2CH3)—终止或中断；Q为氢、卤素、腈基或羟基，或者具有3至6个环原子的可选择取代的一元环碳环或杂环基团；或者具有5至10个环原子的可选择取代的二元环碳环或杂环基团；R4和R5为可选取代基团；R2、R6和R7独立地为氢或具有以下结构的基团 -(Alk3)x-(Z2)y-(Alk4)z-H，其中x、y和z独立地为0或1，Z2为—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—或—C(═O)—O—；Alk3和Alk4为可选择取代的C1-C3烷基、C2-C3烯基或C2-C3炔基基团，可能以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—或—N(CH2CH3)—终止或中断。
• Substituted benzamidines as antibacterial agents
  申请人：Haydon David John

  公开号：US08415383B2

  公开（公告）日：2013-04-09

  Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R3 is a radical of formula -(Alk1)m-(Z1)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z1 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —0—(C═O)—, —C(═O)—O—, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; Alk1 and Alk2 are optionally substituted C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, Or —N(CH2CH3)—; and Q is hydrogen, halogen, nitrile, or hydroxyl, or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; R4 and R5 are optional substituents; and R2, R6 and R7 are independently hydrogen or a radical of formula -(Alk3)x-(Z2)y-(Alk4)z-H wherein x, y and z are independently 0 or 1, Z2 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —0—(C═O)— or —C(═O)—O—; Alk3 and Alk4 are optionally substituted C1-C3 alkylene, C2-C3 alkenylene, or C2-C3 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, or —N(CH2CH3)—.

  式(I A)或(IB)的化合物具有抗菌活性：其中W是═C(H)—或═N—; R3是式-(Alk1)m-(Z1)p-(Alk2)n-Q的基团，其中m、p和n独立地为0或1，但至少有一个为1，Z1是—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—、—C(═O)—O—，或具有3至6个环原子的可选取代二价单环碳环或杂环基团；或具有5至10个环原子的可选取代二价双环碳环或杂环基团；Alk1和Alk2是可选取代的C1-C6烷基、C2-C6烯基或C2-C6炔基基团，可选择以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—或—N(CH2CH3)—结尾或中断；Q是氢、卤素、腈或羟基，或具有3至6个环原子的可选取代单环碳环或杂环基团；或具有5至10个环原子的可选取代双环碳环或杂环基团；R4和R5是可选取代的取代基；R2、R6和R7独立地为氢或式-(Alk3)x-(Z2)y-(Alk4)z-H的基团，其中x、y和z独立地为0或1，Z2是—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—、—N(CH2CH3)—、—C(—O)—、—O—(C═O)—或—C(═O)—O—；Alk3和Alk4是可选取代的C1-C3烷基、C2-C3烯基或C2-C3炔基基团，可选择以—O—、—S—、—S(O)—、—S(O2)—、—NH—、—N(CH3)—或—N(CH2CH3)—结尾或中断。