Diisopropyl-phosphoramidous acid (2S,3S,4S,5S)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester | 121058-88-6

• 物质功能分类: 有机原料 - 氨基化合物 - 酰胺类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Diisopropyl-phosphoramidous acid (2S,3S,4S,5S)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
• 英文别名: (2S,3S,4S,5S)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite；N-[1-[(2S,3S,4S,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
• CAS: 121058-88-6
• 化学式: C₄₇H₆₄N₅O₉PSi
• 分子量: 902.113
• InChiKey: QKWKXYVKGFKODW-ZYRNLWDWSA-N

物化性质

• 溶解度：
  二甲基亚砜：100 mg/ml（110.85 mM）

计算性质

• 辛醇/水分配系数(LogP)：
  9.18
• 重原子数：
  63
• 可旋转键数：
  21
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  153
• 氢给体数：
  1
• 氢受体数：
  11

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

反应信息

• 作为产物：
  描述：

  4-N-acetyl-2',3',5'-tri-O-benzoyl-β-L-cytidine 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Diisopropyl-phosphoramidous acid (2S,3S,4S,5S)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
  参考文献：
  名称：

  L-R_{ibonucleosides for}R_acemicRNA

  摘要：

  Two L-ribosyl donors were synthesised from L-xylose, then submitted to a glycosidation reaction according to Vorbruggen's conditions to furnish L-ribonucleosides in high yield.

  DOI：

  10.1080/15257779908041544

文献信息

• L-R_{ibonucleosides for}R_acemicRNA
  作者：E. Moyroud、O. Botta、P. Strazewski

  DOI：10.1080/15257779908041544

  日期：1999.4

  Two L-ribosyl donors were synthesised from L-xylose, then submitted to a glycosidation reaction according to Vorbruggen's conditions to furnish L-ribonucleosides in high yield.