N-（2-巯基-1-氧丙基）-L-丝氨酸 | 1313496-17-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-（2-巯基-1-氧丙基）-L-丝氨酸
• 英文名称: Ser-tiopronin
• 英文别名: N-(2-Mercapto-1-oxopropyl)-L-serine；(2S)-3-hydroxy-2-(2-sulfanylpropanoylamino)propanoic acid
• CAS: 1313496-17-1
• 化学式: C₆H₁₁NO₄S
• 分子量: 193.224
• InChiKey: NGCWQOJBMCFVRB-BKLSDQPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  87.6
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] METHODS OF TREATING CANCER AND OTHER DISEASES<br/>[FR] MÉTHODES DE TRAITEMENT DU CANCER ET D'AUTRES MALADIES
  申请人：US HEALTH

  公开号：WO2012058269A2

  公开（公告）日：2012-05-03

  Disclosed are a method of treating cancer in a cell, a method of enhancing the chemotherapeutic treatment of a cancer treatment agent, a method of reducing resistance of a cancer cell to a chemotherapeutic agent, a method of reducing the amount or activity of an ABC-family mRNA and/or protein, a method of reducing the amount or activity of the ABCB1 mRNA and/or protein or the ABCC1 mRNA and/or protein in an animal cell undergoing cancer treatment, a method of reducing the amount or activity of glutathione and/or Bcl2 in the cancer cell, a method of treating other multidrug resistant diseases, and a method of treating a multidrug resistant cell such as a bacterial multidrug resistant Staphylococcus aureus (MRSA), tuberculosis, fungal infection, or MDR malaria, by administering a compound of the Formula (I): a diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein R1-R4 are as described herein. Also disclosed are pharmaceutical compositions comprising a compound of formula (I), a diastereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.