N-（3-丁烯基）伪丁丙诺非 | 457071-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: N-（3-丁烯基）伪丁丙诺非
• 英文名称: N-(3-Butenyl)norbuprenorphine
• 英文别名: (1S,2S,6R,14R,15R,16R)-5-but-3-enyl-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
• CAS: 457071-73-7
• 化学式: C₂₉H₄₁NO₄
• 分子量: 467.6
• InChiKey: OLKNJLQXKYIUDJ-IHFGGWKQSA-N

物化性质

• 沸点：
  590.6±50.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)
• 溶解度：
  碱性酒精（少量溶解）、氯仿（少量溶解）

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  62.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Acetate salt of buprenorphine and methods for preparing buprenorphine
  申请人：Rhodes Technologies

  公开号：US10278967B2

  公开（公告）日：2019-05-07

  The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.

  本公开提供了丁丙诺啡的乙酸盐及其无水物、溶液、水合物和结晶形式，其中丁丙诺啡的乙酸盐基本上不含杂质。本公开进一步提供了制备乙酸盐、由乙酸盐制备的丁丙诺啡游离基、由游离基制备的其他盐及其药物组合物的方法，这些方法基本上不含杂质。
• ACETATE SALT OF BUPRENORPHINE AND METHODS FOR PREPARING BUPRENORPHINE
  申请人：Rhodes Technologies

  公开号：US20170197975A1

  公开（公告）日：2017-07-13

  The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
• US9926329B2
  申请人：——

  公开号：US9926329B2

  公开（公告）日：2018-03-27