N1,N10-二乙酰基三乙烯四胺 | 141998-22-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N1,N10-二乙酰基三乙烯四胺
• 中文别名: N1,N10-二乙酰三亚乙基四胺；N1,N1-二乙酰三亚乙基四胺
• 英文名称: N,N'-diacetyl-3,6-diazaoctane-1,8-diamine
• 英文别名: N1,N10-diacetyltriethylenetetramine；DAT；N1,N10-Diacetyl Triethylenetetramine；N-[2-[2-(2-acetamidoethylamino)ethylamino]ethyl]acetamide
• CAS: 141998-22-3
• 化学式: C₁₀H₂₂N₄O₂
• 分子量: 230.31
• InChiKey: WJZSOPBEHMQITR-UHFFFAOYSA-N

物化性质

• 熔点：
  55-57°C
• 溶解度：
  可溶于氯仿、DMSO（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三乙烯四胺 、 α-D(+)-五乙酰葡萄糖 以 乙醇 为溶剂， 反应 20.0h， 以49%的产率得到N1,N10-二乙酰基三乙烯四胺
  参考文献：
  名称：

  单或双乙酰化聚乙烯聚亚胺衍生物的区域专一性合成

  摘要：

  摘要 以α-D-五乙酰基葡萄糖为乙酰化剂合成了乙酰化聚乙烯多胺CH3CONHCH2(CH2-NH-CH2)CH2NH2 (n=1,2;)。

  DOI：

  10.1080/00397919208019313

文献信息

• USE OF TRIETHYLENETETRAMINE (TETA) FOR THE THERAPEUTIC INDUCTION OF AUTOPHAGY
  申请人：INSERM (Institut National de la Ssnté et de la Researche Médecale)

  公开号：US20200360305A1

  公开（公告）日：2020-11-19

  Autophagy is a universal anti-aging mechanism the chronic induction of which can extend the health span and lifespan of mammals Here the inventors show that triethylenetetramine (TETA), also called trientine, a drug that is approved for the treatment of Wilson disease, can induce autophagy in mouse tissues in vivo. In particular, chronic autophagy stimulation by TETA can improve the metabolic characteristics of mice kept on a high-fat or high-sugar diet without reducing their food uptake, yet attenuating their weight gain. TETA attenuates adioposity, signs of obesity related type-2 diabetes and hepatosteatosis. TETA also mediates hepatoprotective effects against acute ethanol intoxication. Hence, TETA can be considered as a novel autophagy-inducing agent and thus can be used for the treatment of various diseases and in particular for the treatment of obesity, as well as obesity-related comorbidities.
• TREATMENT OF COPPER DISORDER
  申请人：PhilERA New Zealand Ltd.

  公开号：US20220280451A1

  公开（公告）日：2022-09-08

  The present disclosure relates to compositions comprising fixed doses of triethylenetetramine disuccinate, and methods for their use in the prophylaxis and treatment of copper-related diseases, disorders and conditions.
• [EN] TREATMENT OF COPPER DISORDERS<br/>[FR] TRAITEMENT DE TROUBLES LIÉS AU CUIVRE
  申请人：[en]PHILERA NEW ZEALAND

  公开号：WO2022187709A1

  公开（公告）日：2022-09-09

  The present disclosure relates to compositions comprising fixed doses of triethylenetetramine disuccinate, and methods for their use in the prophylaxis and treatment of copper-related diseases, disorders and conditions.
• Regiospecific Synthesis of Mono-Or Diacetylated Polyethylenepol Yamine Derivatives
  作者：Gabriela Kuswik-Rabiega、Fred W. Bruenger、Scott C. Miller

  DOI：10.1080/00397919208019313

  日期：1992.5

  Abstract Acetylated polyethylenepolyamines CH3CONHCH2(CH2-NH-CH2)CH2NH2 (n=1,2;) were synthesized using α-D-pentaacetyl-glucose as an acetylating agent.

  摘要 以α-D-五乙酰基葡萄糖为乙酰化剂合成了乙酰化聚乙烯多胺CH3CONHCH2(CH2-NH-CH2)CH2NH2 (n=1,2;)。