N2-乙酰基-精氨酸 | 35436-73-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N2-乙酰基-精氨酸
• 英文名称: N-acetyl arginine
• 英文别名: Nα-acetylarginine；2-Acetamido-5-(diaminomethylideneazaniumyl)pentanoate
• CAS: 35436-73-8
• 化学式: C₈H₁₆N₄O₃
• mdl: MFCD00063012
• 分子量: 216.24
• InChiKey: SNEIUMQYRCDYCH-UHFFFAOYSA-N

物化性质

• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  131
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  N2-乙酰基-精氨酸 生成 N-乙酰基-D-精氨酸二水合物
  参考文献：
  名称：

  肽的研究。二。D-组胺基-D-苯丙氨酰-D-精氨酸-D-三苯甲基丙氨酸的合成及其生理特性。

  摘要：

  DOI：

  10.1021/ja01087a032
• 作为产物：
  描述：

  乙烯酮 、 L-精氨酸 在 水 作用下， 生成 N2-乙酰基-精氨酸
  参考文献：
  名称：

  Neuberger, Biochemical Journal, 1938, vol. 32, p. 1455

  摘要：

  DOI：

文献信息

• Novel heteroaryl peptidomimetics as thrombin receptor antagonists
  申请人：——

  公开号：US20040138141A1

  公开（公告）日：2004-07-15

  The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

  这项发明涉及一种新颖的杂环芳基肽类似物化合物，可用作治疗与血栓形成、再狭窄、高血压、心力衰竭、心律失常、炎症、心绞痛、中风、动脉粥样硬化、缺血性疾病、血管生成及相关疾病、癌症和神经退行性疾病相关的疾病的凝血酶受体拮抗剂。本发明涉及包含所述替代杂环芳基肽类似物的药物组合物以及治疗由凝血酶受体介导的疾病的方法。
• [EN] MITOCHONDRIA-TARGETED DICARBONYL SEQUESTERING COMPOUNDS<br/>[FR] COMPOSÉS DE SÉQUESTRATION DE GROUPES DICARBONYLES CIBLANT LES MITOCHONDRIES
  申请人：MEDICAL RES COUNCIL

  公开号：WO2015075200A1

  公开（公告）日：2015-05-28

  The invention relates to compounds having Formula (1): A-L-B or pharmaceutically acceptable salts thereof, wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention also relates to pharmaceutical compositions containing such compounds and salts, and to the use of such compounds and salts for treating diabetes, preferably hyperglycaemic diabetes. A mass spectrometry probe and to a method of labelling a biological molecule 1 for mass spectrometry detection are also described.

  该发明涉及具有Formula（1）的化合物：A-L-B或其药用盐，其中：A是包含取代芳基或取代杂环芳基的二羰基螯合基团；L是可选的连接基团；B是线粒体靶向基团。该发明还涉及含有这种化合物和盐的药物组合物，以及利用这种化合物和盐治疗糖尿病，尤其是高血糖糖尿病的用途。还描述了一种质谱探针和一种用于质谱检测生物分子的标记方法。
• COMPOSITIONS FOR REDUCING RISK OF ADVERSE EVENTS CAUSED BY DRUG-DRUG INTERACTIONS
  申请人：JENKINS Thomas E.

  公开号：US20120232066A1

  公开（公告）日：2012-09-13

  The present disclosure provides a composition comprising a GABA A agonist and a GI enzyme inhibitor. The present disclosure also provides a composition comprising (a) a GI enzyme inhibitor and (b) a first drug that interacts with a second drug to produce an adverse effect when the second drug is co-ingested as a GI enzyme-cleavable prodrug with the first drug. Such an interaction can be additive or synergistic.

  本公开提供一种包含GABAA激动剂和GI酶抑制剂的组合物。本公开还提供一种包含（a）GI酶抑制剂和（b）第一药物的组合物，当第二药物以GI酶可切割的前药形式与第一药物共同摄入时，第一药物与第二药物相互作用产生不良效应。这种相互作用可以是加成的或协同的。
• Isolation and Identification of 5-Methyl-imidazolin-4-one Derivative as Glyceraldehyde-Derived Advanced Glycation End Product
  作者：Teruyuki USUI、Hirohito WATANABE、Fumitaka HAYASE

  DOI：10.1271/bbb.50584

  日期：2006.6.23

  We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and Nα-acetylarginine. A major product was identified as Nα-acetyl-Nδ-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.

  我们分离并鉴定了由甘油醛和 Nα-乙酰精氨酸形成的甘油醛衍生的高级糖基化产物 (AGE)。主要产物被鉴定为Nα-乙酰基-Nδ-(5-甲基-咪唑啉-4-酮-2-基)-鸟氨酸。据报道，该化合物为甲基乙二醛衍生的 AGE，MG-H1。这项研究表明 MG-H1 是通过甘油醛相关和甲基乙二醛相关途径形成的。 MG-H1有可能成为甘油醛和甲基乙二醛相关酶损伤的指标。
• Cosmetic composition
  申请人：AJINOMOTO CO., INC.

  公开号：US20030165448A1

  公开（公告）日：2003-09-04

  A cosmetic composition for skin and/or hair, which comprises at least one kind of substance selected from the group consisting of an N &agr; ,N G -di-acylarginine, for example, a compound represented by the following general formula (I): 1 wherein R 1 and R 2 each independently represents a straight or branched-chain alkyl group having 1 to 21 carbon atoms or a straight or branched-chain alkenyl group having 2 to 21 carbon atoms. The cosmetic composition imparts much moistness and superior conditioning effects such as body or elasticity to hair, and to skin, said composition does not impart tackiness and blocked feeling, whilst imparts superior feeling of use such as moistness.

  一种用于皮肤和/或头发的化妆品组合物，其包含以下所述组中选择的至少一种物质，即N&agr;，NG-二酰基精氨酸，例如，由下述一般式（I）表示的化合物：其中R1和R2各自独立地表示具有1至21个碳原子的直链或支链烷基或具有2至21个碳原子的直链或支链烯基。该化妆品组合物为头发提供了很多湿润和优越的调理效果，例如体积或弹性，而对于皮肤，该组合物不会产生黏腻和堵塞感，同时提供了优越的使用感，例如湿润感。