(1-methoxycarbonyl-2-oxo-cyclohexyl)-acetic acid methyl ester | 1195459-24-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (1-methoxycarbonyl-2-oxo-cyclohexyl)-acetic acid methyl ester
• 英文别名: (+/-)-1-Methoxycarbonylmethyl-2-oxo-cyclohexancarbonsaeure-methylester；(1-Methoxycarbonyl-2-oxo-cyclohexyl)-essigsaeure-methylester；Methyl 1-(2-methoxy-2-oxoethyl)-2-oxocyclohexane-1-carboxylate
• CAS: 1195459-24-5
• 化学式: C₁₁H₁₆O₅
• 分子量: 228.245
• InChiKey: RBAOPXHSGSYAME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  溴乙酸甲酯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (1-methoxycarbonyl-2-oxo-cyclohexyl)-acetic acid methyl ester
  参考文献：
  名称：

  Fat embolism syndrome and elective knee arthroplasty

  摘要：

  Purpose: To report a case of fat embolism syndrome (FES) following elective left knee arthroplasty and review the diagnosis, investigation, prevention and perioperative management of this condition.Clinical features: A 76-yr-old lady presented for left total knee arthroplasty under general anesthesia. After an uneventful anesthetic and initial recovery, she developed respiratory and neurological complications six hours postoperatively necessitating supportive care in the intensive care unit. Following extensive investigation, a clinical diagnosis of FES was made 48 hr postoperatively supported by the development of diffuse encephalopathy, thrombocytopenia, hypoxemia, chest petechiae and chest x-ray changes. A magnetic resonance imaging scan five days postoperatively confirmed this diagnosis. Her postoperative course showed gradual improvement consistent with a slowly resolving encephalopathy.Previous published cases of FES associated with knee arthroplasty present either with intraoperative cardiorespiratory collapse or, as with this patient, in the postoperative period with respiratory, cardiovascular and/or cerebral dysfunction.Conclusions: The clinical diagnosis of FES is essentially one of exclusion, supported by laboratory and radiological investigations. Preoperative identification of at-risk patients, use of appropriate invasive perioperative monitoring and modified surgical techniques may minimize the development of the syndrome. Treatment is supportive.

  DOI：

  10.1007/bf03020414

文献信息

• New Compounds. Some Derivatives of 2-Carbomethoxycyclohexanone
  作者：Milton Soffer、Roberta Stewart

  DOI：10.1021/ja01142a602

  日期：1952.11
• Fat embolism syndrome and elective knee arthroplasty
  作者：Kathryn Jenkins、Frances Chung、Richard Wennberg、Edward E. Etchells、Rod Davey

  DOI：10.1007/bf03020414

  日期：2002.1

  Purpose: To report a case of fat embolism syndrome (FES) following elective left knee arthroplasty and review the diagnosis, investigation, prevention and perioperative management of this condition.Clinical features: A 76-yr-old lady presented for left total knee arthroplasty under general anesthesia. After an uneventful anesthetic and initial recovery, she developed respiratory and neurological complications six hours postoperatively necessitating supportive care in the intensive care unit. Following extensive investigation, a clinical diagnosis of FES was made 48 hr postoperatively supported by the development of diffuse encephalopathy, thrombocytopenia, hypoxemia, chest petechiae and chest x-ray changes. A magnetic resonance imaging scan five days postoperatively confirmed this diagnosis. Her postoperative course showed gradual improvement consistent with a slowly resolving encephalopathy.Previous published cases of FES associated with knee arthroplasty present either with intraoperative cardiorespiratory collapse or, as with this patient, in the postoperative period with respiratory, cardiovascular and/or cerebral dysfunction.Conclusions: The clinical diagnosis of FES is essentially one of exclusion, supported by laboratory and radiological investigations. Preoperative identification of at-risk patients, use of appropriate invasive perioperative monitoring and modified surgical techniques may minimize the development of the syndrome. Treatment is supportive.