3-Propylpyrazolo[1,5-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 3-Propylpyrazolo[1,5-a]pyridine
• 英文别名: 3-propylpyrazolo[1,5-a]pyridine
• 化学式: C₁₀H₁₂N₂
• 分子量: 160.22
• InChiKey: KTPMUGIBFLASBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• 5-MEMBERED AND BICYCLIC HETEROCYCLIC AMIDES AS INHIBITORS OF ROCK
  申请人：Bristol-Myers Squibb Company

  公开号：EP3652168B1

  公开（公告）日：2021-06-30
• FUSED BICYCLIC COMPOUNDS USEFUL AS UBIQUITIN-SPECIFIC PEPTIDASE 30 INHIBITORS
  申请人：FORMA THERAPEUTICS, INC.

  公开号：US20210198263A1

  公开（公告）日：2021-07-01

  The present disclosure relates to compounds of formula (I′) and pharmaceutically acceptable salts thereof useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), pharmaceutical compositions thereof, and methods of use thereof. Compounds as disclosed herein can be useful in the treatment of a disease or disorder involving mitochondrial dysfunction, including neurodegenerative diseases.