N~1~,n~1~,4-三甲基-1,2-苯二胺 | 183251-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N~1~,n~1~,4-三甲基-1,2-苯二胺
• 英文名称: 2-Dimethylamino-5-methylanilin
• 英文别名: 2-dimethylamino-5-methylaniline；4,N¹,N¹-trimethyl-o-phenylenediamine；4,N¹,N¹-Trimethyl-o-phenylendiamin；3-Amino-4-dimethylamino-toluol；N1,N1,4-Trimethylbenzene-1,2-diamine；1-N,1-N,4-trimethylbenzene-1,2-diamine
• CAS: 183251-82-3
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: VBPHFCKSOJIZJU-UHFFFAOYSA-N

物化性质

• 沸点：
  265.0±28.0 °C(Predicted)
• 密度：
  1.029±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2921590090

反应信息

• 作为反应物：
  描述：

  N~1~,n~1~,4-三甲基-1,2-苯二胺 在 盐酸 、 tin(ll) chloride 作用下， 生成 N,N'-(2-dimethylamino-5-methyl-p-phenylene)-bis-acetamide
  参考文献：
  名称：

  Pinnow; Matcovich, Chemische Berichte, 1898, vol. 31, p. 2518

  摘要：

  DOI：
• 作为产物：
  描述：

  4,N,N-trimethyl-2-nitroaniline 在 水 、 sodium hydroxide 、 锌 作用下， 以 乙醇 为溶剂， 以70%的产率得到N~1~,n~1~,4-三甲基-1,2-苯二胺
  参考文献：
  名称：

  具有双齿苯胺配体的六配位铀配合物

  摘要：

  报道了一种新的双齿苯胺配体和四种使用该配体的铀酰胺配合物的合成。二级苯胺 HN[ R ]Ar MeL (R = C(CD 3 ) 2 CH 3 , Ar MeL = 2-NMe 2 -5-MeC 6 H 3 ) 由 H 2 NAr MeL 和丙酮-d 6 缩合制备然后用 MeLi 将所得亚胺烷基化。配体前体 (Et 2 O)Li(N[ R ]Ar MeL ) 和 K(N[ R ]Ar MeL ) 分别通过 HN[ R ]Ar MeL 与 n-BuLi 和 KH 的去质子化制备。用 (Et 2 O)Li(N[ R ]Ar MeL ) (2 equiv) 处理 UI 3 (THF) 4 提供了铀 (III)-ate 络合物 Li[I 2 U(N[ R ]Ar MeL ) 2 ] (Li[1])，同时用三个等价物处理 UI 3。K(N[ R ]Ar MeL ) 提供中性铀 (III) 配合物 U(N[

  DOI：

  10.1016/j.crci.2010.05.001

文献信息

• TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE
  申请人：Wang Yong

  公开号：US20140128384A1

  公开（公告）日：2014-05-08

  The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.

  本发明涉及肿瘤靶向药物康柏他丁A4的咪唑、噁唑和噻唑衍生物，以及磷酸酯、磺酸酯或药用可接受的盐、糖苷衍生物、其溶剂合物，其中A环包括在4位有取代基的3,5-二甲氧基苯基基团。药理活性测定表明，本发明的化合物在体外具有良好的抗肿瘤活性和优秀的微管抑制作用。
• Biodegradable microspheres as a carrier for macromolecules
  申请人：The University of Kentucky Research Foundation

  公开号：EP0245820A2

  公开（公告）日：1987-11-19

  A method for preparing biodegradable micro­spheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble mono­vinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.

  一种制备具有三维网络的生物可降解微球的方法，生物活性大分子制剂被物理地包裹在其中。 该微球能够以可控速率释放大分子制剂。 该方法包括将生物可降解亲水性聚合物的乙烯基衍生物、水溶性单乙烯基单体和生物活性大分子在水中乳化，并使生物可降解亲水性聚合物和水溶性单乙烯基单体共聚，从而使生物活性大分子被包裹在其中。
• Dental restoration composition
  申请人：SANKIN KOGYO KABUSHIKI KAISHA

  公开号：EP0509516A2

  公开（公告）日：1992-10-21

  A two-part dental restoration composition composed of a powder and a liquid which are to be combined and evenly mixed prior to usage. The powder is to be composed of a fluoride-containing and releasing filler having an average particulate size under one micron, an acid accelerator and a tertiary amine. The liquid is composed of hydrophilic, high viscosity phosphate which is diluted with a low viscosity monomer hydrophobic pyrophosphate diluent. This phosphate composition is combined with a dimethacrylate binder and a photoinitiator.

  一种由粉末和液体组成的双组分牙科修复组合物，使用前要将粉末和液体混合并均匀搅拌。粉末由平均粒径小于一微米的含氟释放填料、酸促进剂和叔胺组成。液体由亲水性高粘度磷酸盐组成，并用低粘度单体疏水性焦磷酸盐稀释剂稀释。这种磷酸盐组合物与二甲基丙烯酸酯粘合剂和光引发剂结合在一起。
• A dental cement composition
  申请人：SANKIN KOGYO KABUSHIKI KAISHA

  公开号：EP0797975A2

  公开（公告）日：1997-10-01

  A practically non-aqueous dental cement composition is disclosed and the dental cement composition comprises a polymer or co-polymer having an α,β-unsaturated carboxylic acid as an essential component of a main monomer; and an inorganic powder capable of forming a metal chelate in the presence of water characterized in that the polymer or co-polymer exists as a solution in a polymerizable monomer that can dissolve the polymer or co-polymer. To provide a dental composition which has not only the advantages of the conventional glass ionomer cement but also a higher setting rate and more desirable physical properties of the setting product and is excellent also in durability, by eliminating the disadvantages in the setting rate and physical properties of the set cement.

  本发明公开了一种几乎不含水的牙科水门汀组合物，该牙科水门汀组合物包括一种聚合物或共聚物，其主单体的基本成分为α，β-不饱和羧酸；以及一种无机粉末，该无机粉末能够在有水的情况下形成金属螯合物，其特征在于该聚合物或共聚物以溶液形式存在于可聚合单体中，该单体能够溶解该聚合物或共聚物。 提供一种牙科组合物，该组合物不仅具有传统玻璃离子水泥的优点，而且具有更高的固化率和更理想的固化产品物理性能，并且通过消除固化水泥在固化率和物理性能方面的缺点，还具有优异的耐久性。
• DENTAL PRIMER COMPOSITION AND POLYMERIZATION CATALYST
  申请人：TOKUYAMA CORPORATION

  公开号：EP0811368A1

  公开（公告）日：1997-12-10

  There is provided a dental primer composition capable of obtaining high adhesive strength to both dentin and enamel, as a pretreatment material for a chemically polymerizable adhesive. This composition is a dental primer composition comprising a polymerizable monomer containing an acidic group, water, aryl borate and transition metal compound.

  本发明提供了一种牙科处理剂组合物，作为化学可聚合粘合剂的预处理材料，能够获得对牙本质和珐琅质的高粘合强度。这种组合物是一种牙科处理剂组合物，由含有酸性基团的可聚合单体、水、硼酸芳基酯和过渡金属化合物组成。