1-<(2-hydroxyethoxy)methyl>-cyclopentanopyrimidine-2,4-dione | 110232-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-<(2-hydroxyethoxy)methyl>-cyclopentanopyrimidine-2,4-dione
• 英文别名: 1-(2-hydroxyethoxymethyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-dione
• CAS: 110232-04-7
• 化学式: C₁₀H₁₄N₂O₄
• 分子量: 226.232
• InChiKey: UNXHVRZDAQJCLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-<(2-hydroxyethoxy)methyl>-cyclopentanopyrimidine-2,4-dione 在 sodium azide 作用下， 以 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 1-<(2-azidoethoxy)methyl>-cyclopentanopyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and Antiviral Study of Cyclopentano [d] Pyrimidine-2,4-diones and Octahydroquinazoline-2,4-diones Acyclic Nucleosides as Potential Anti-HIV Agents

  摘要：

  The Vorbruggen and Niedballa's method((1)) afforded new cycropentano [d] pyrimidine-2,4-dione and octahydroquinazoline-2,4-dione nucleosides. Various modifications of these new derivatives enabled us to obtain HEPT related compounds which were tested against Human Immunodeficiency Virus-1 (HIV-1). Unfortunately, none of these compounds showed significant antiviral activity.

  DOI：

  10.1080/15257779408011863
• 作为产物：
  描述：

  6,7-二氢-1H-环戊并[D]嘧啶-2,4(3H,5H)-二酮 在 ammonium sulfate 、 氨 、 四氯化锡 、 六甲基二硅氮烷 作用下， 以 甲醇 为溶剂， 反应 40.0h， 生成 1-<(2-hydroxyethoxy)methyl>-cyclopentanopyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and Antiviral Study of Cyclopentano [d] Pyrimidine-2,4-diones and Octahydroquinazoline-2,4-diones Acyclic Nucleosides as Potential Anti-HIV Agents

  摘要：

  The Vorbruggen and Niedballa's method((1)) afforded new cycropentano [d] pyrimidine-2,4-dione and octahydroquinazoline-2,4-dione nucleosides. Various modifications of these new derivatives enabled us to obtain HEPT related compounds which were tested against Human Immunodeficiency Virus-1 (HIV-1). Unfortunately, none of these compounds showed significant antiviral activity.

  DOI：

  10.1080/15257779408011863

文献信息

• Synthesis and Antiviral Study of Cyclopentano [<i>d</i>] Pyrimidine-2,4-diones and Octahydroquinazoline-2,4-diones Acyclic Nucleosides as Potential Anti-HIV Agents
  作者：J. Renault、D. Laduree、M. Robba

  DOI：10.1080/15257779408011863

  日期：1994.5

  The Vorbruggen and Niedballa's method((1)) afforded new cycropentano [d] pyrimidine-2,4-dione and octahydroquinazoline-2,4-dione nucleosides. Various modifications of these new derivatives enabled us to obtain HEPT related compounds which were tested against Human Immunodeficiency Virus-1 (HIV-1). Unfortunately, none of these compounds showed significant antiviral activity.