3-Methyl-2-phenyl-morpholine-4-carboxylic acid ethyl ester | 127634-96-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-Methyl-2-phenyl-morpholine-4-carboxylic acid ethyl ester
• 英文别名: Ethyl 3-methyl-2-phenylmorpholine-4-carboxylate
• CAS: 127634-96-2
• 化学式: C₁₄H₁₉NO₃
• 分子量: 249.31
• InChiKey: WGYKDDZEQMGRDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Methyl-2-phenyl-morpholine-4-carboxylic acid ethyl ester 在 盐酸 、 硫酸 作用下， 生成 3-甲基-2-苯基吗啉盐酸盐
  参考文献：
  名称：

  Synthesis, Toxicological, and Pharmacological Assessment of Derivatives of 2-Aryl-4-(3-arylpropyl)morpholines

  摘要：

  The synthesis of nine original morpholine derivatives, i.e.2-aryl-4-(3-arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and H-1-NMR, and some C-13-NMR. Acute toxicity studies of the compounds of them by were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time; locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4-(2-benzoylethyl)-2-phenyl-3-methyl) morpholine 4e was studied for MAO-A and MAO-B inhibition in vitro in rat brain mitochondria preparations.

  DOI：

  10.1002/(sici)1521-4184(199811)331:11<342::aid-ardp342>3.0.co;2-6
• 作为产物：
  描述：

  2-Phenyl-3-methyl-4-aethyl-morpholin 、 氯甲酸乙酯 生成 3-Methyl-2-phenyl-morpholine-4-carboxylic acid ethyl ester
  参考文献：
  名称：

  AVRAMOVA, P.;JORDANOVA, K.;GAGAUZOV, J., FARMATSIYA, 39,(1989) N, S. 1-5

  摘要：

  DOI：

文献信息

• AVRAMOVA, P.;JORDANOVA, K.;GAGAUZOV, J., FARMATSIYA, 39,(1989) N, S. 1-5
  作者：AVRAMOVA, P.、JORDANOVA, K.、GAGAUZOV, J.

  DOI：——

  日期：——
• Synthesis, Toxicological, and Pharmacological Assessment of Derivatives of 2-Aryl-4-(3-arylpropyl)morpholines
  作者：Petya Avramova、Nicolai Danchev、Rossen Buyukliev、Tatiana Bogoslovova

  DOI：10.1002/(sici)1521-4184(199811)331:11<342::aid-ardp342>3.0.co;2-6

  日期：1998.11

  The synthesis of nine original morpholine derivatives, i.e.2-aryl-4-(3-arylpropyl)morpholines, is described. The structure of all synthesised derivatives was proved by IR and H-1-NMR, and some C-13-NMR. Acute toxicity studies of the compounds of them by were performed on mice. A comparative pharmacological study of the in vivo effects on the central nervous system was undertaken using the screening tests: hexobarbital induced sleeping time; locomotor activity; and behaviour despair (for antidepressive activity). The most active compound 4-(2-benzoylethyl)-2-phenyl-3-methyl) morpholine 4e was studied for MAO-A and MAO-B inhibition in vitro in rat brain mitochondria preparations.