6-methoxy-4,7-dimethyl-1-indanone | 57122-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 6-methoxy-4,7-dimethyl-1-indanone
• 英文别名: 6-methoxy-4,7-dimethyl-2,3-dihydro-1H-inden-1-one；6-Methoxy-4,7-dimethyl-indan-1-on；6-methoxy-4,7-dimethyl-indan-1-one；4,7-dimethyl-6-methoxy-1-indanone；6-methoxy-4,7-dimethyl-2,3-dihydroinden-1-one
• CAS: 57122-11-9
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: RYTPFGQKVUSVBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-methoxy-4,7-dimethyl-1-indanone 在 盐酸 、 聚合甲醛 、 亚硝酸丁酯 、 溶剂黄146 作用下， 以 正丁醇 、 苯 为溶剂， 反应 4.17h， 生成 3-Methoxy-1,4,7,8-tetramethyl-11H-indeno[1,2-b]quinoxaline
  参考文献：
  名称：

  Merchant, J. R.; Upasani, R. B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 9, p. 863 - 865

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5-二甲基苯甲醚 以35%的产率得到
  参考文献：
  名称：

  MERCHANT J.R.; KAMATH M.S.; DIKE S.Y., J. CHEM. SOC. PERKIN TRANS. 1977, PART 1 NO 19, 1977

  摘要：

  DOI：

文献信息

• Phenol derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05162571A1

  公开（公告）日：1992-11-10

  Novel phenol derivatives of the general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X, Y and n are as defined in the specification, which have therapeutic and prophylactic activities against cerebral, cardiac, renal and pulmonary circulatory system diseases, respiratory diseases, allergy, anaphylactic shock, endotoxin shock, inflammation and the like as well as inhibiting activities against vascularization by oncocytes.

  具有以下一般式的新型酚衍生物：##STR1## 其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、X、Y和n如规范中定义的那样，具有对大脑、心脏、肾脏和肺部循环系统疾病、呼吸系统疾病、过敏、过敏性休克、内毒素休克、炎症等的治疗和预防活性，以及对肿瘤细胞血管化的抑制活性。
• A patient with type I CD36 deficiency whose myocardium accumulated123I-BMIPP after 4 years
  作者：Kazuki Ito、Hiroki Sugihara、Takuji Tanabe、Kan Zen、Takatou Hikosaka、Yoshihiko Adachi、Shuji Katoh、Akihiro Azuma、Masao Nakagawa

  DOI：10.1007/bf02987845

  日期：2001.6

  A 73-year-old man with aortic regurgitation was examined by I-123-alpha -methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial single photon emission computed tomography (SPECT) in 1995. Myocardial accumulation was not evident on either the early or the delayed image obtained 15 minutes and 3 hours, respectively, after injecting I-123-BMIPP. Flow cytometric analysis of CD36 expression in monocytes and platelets identified a type I CD36 deficiency. The patient was hospitalized for severe heart failure in 1999. Upon admission, the cardiothoracic ratio on chest Xrays was 73%, and the left ventricular end-diastolic diameter on echocardiograms was enlarged to 77 mm. On the second day, we performed I-123-BMIPP myocardial SPECT. Myocardial accumulation was evident in the delayed, but not in the early image. We repeated I-123-BMIPP myocardial SPECT on the 10th day after admission. Myocardial accumulation was evident on both early and delayed images. Tc-99m-tetrofosmin myocardial SPECT was immediately performed after I-123-BMIPP myocardial SPECT to distinguish myocardial from pooling images in the left ventricle, but, because the images from both 99mTc-tetrofosmin and I-123-BMIPP myocardial SPECT were idential, we considered that the 123I-BMIPP myocardial SPECT images reflected the actual myocardial condition.The CD36 molecule transports long-chain fatty acid (LCFA) on the myocardial membrane, but I-123-BMIPP scintigraphy does not show any myocardial accumulation in patients with type I CD36 deficiency, indicating that myocardial LCFA uptake occurs through CD36 on the human myocardial membrane. Even though our patient had type I CD36 deficiency, BMIPP was uptaken by the myocardium during heart failure, suggesting a variant pathway on the human myocardial membrane for LCFA uptake.
• Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives
  作者：Shoji Fukumoto、Mitsuru Shiraishi、Zenichi Terashita、Yasuko Ashida、Yoshiyuki Inada

  DOI：10.1021/jm00090a009

  日期：1992.6

  Consideration of possible structural similarities between thromboxane A2 and the hydroquinone form of (R)-(+)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid (R-(+)-AA-2414) led to the development of a new series of thromboxane A2/prostaglandin H-2 (TXA2/PGH2) receptor antagonists, namely 7-(4-fluorophenyl)-7-(2-hydroxyphenyl)heptanoic acids (I). These compounds were found to be potent TXA2/PGH2 receptor antagonists. Compounds having either a carbonyl or a hydroxymethyl group at the para-position of the phenolic hydroxy group exhibited most potent activities in this series. Compounds 14, 15, 18, and 26 inhibited the specific binding of [H-3]U-46619 to guinea pig platelet membranes (IC50 = 4.4, 80, 32, and 13 nM, respectively), and also inhibited U-46619-induced human platelet aggregation (IC50 = 310, 69, 79, and 78 nM, respectively). Comparison of the UV spectra of the compounds with a carbonyl group at the para-position of phenolic hydroxy group revealed that the activity tended to increase in accordance with a decrease in the torsional angle between the carbonyl group and the phenol ring. These results suggested that the spacial location of the carbonyl and hydroxymethyl oxygen are important for significant increase in activity and that the carbonyl and hydroxymethyl oxygen at the para-position of the phenolic hydroxy group might interact with one of the TXA2/PGH2 receptor sites.
• Regioselective Synthesis of Indanones
  作者：Ben Feringa、Thomas van Leeuwen、Thomas Neubauer

  DOI：10.1055/s-0033-1339156

  日期：——

  The degree of hydrolysis of polyphosphoric acid (PPA) has a crucial effect on the regioselectivity of the PPA-mediated synthesis of indanones. It was found that the regioselectivity can be switched by employing PPA with either a high or low content of P2O5. This methodology was used for the regioselective synthesis of a range of electron-rich indanones, including a natural sesquiterpene.
• DIKE S. Y.; KAMATH M. S.; MERCHANT J. R., INDIAN J. CHEM., 1979, B 17, NO 4, 336-338
  作者：DIKE S. Y.、 KAMATH M. S.、 MERCHANT J. R.

  DOI：——

  日期：——