O-(4-羟基-3-碘苯基)-3,5-二碘-L-酪氨酸盐酸盐

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: O-(4-羟基-3-碘苯基)-3,5-二碘-L-酪氨酸盐酸盐
• 中文别名: 盐酸碘塞罗宁
• 英文名称: (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid;hydron;chloride
• 化学式: C15H13ClI3NO4
• 分子量: 687.43
• InChiKey: HFEMPWKWYHWPQX-YDALLXLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.37
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  92.8
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Uses for thyroid hormone compounds
  申请人：KARO BIO AB

  公开号：EP1398024A2

  公开（公告）日：2004-03-17

  A skin treatment composition for topical application comprises: at least one thyroid hormone compound or thyroid hormone-like compound, wherein said thyroid hormone compound or thyroid hormone-like compound is a chemical entity which binds to TRα or TRβ with a dissociation constant, Kd, lower than 1µM, whereinKd = [R] • [L] / [RL], wherein [R] is the concentration of receptor, [L] is the concentration of ligand and [RL] is the concentration of the receptor-ligand complex; at least one ingredient selected from vitamin D, glucocorticoids, retinoids and retinoic acid receptor binding compounds, or analogues thereof; and a pharmacologically acceptable base.

  一种用于局部应用的皮肤治疗组合物包括至少一种甲状腺激素化合物或甲状腺激素样化合物，其中所述甲状腺激素化合物或甲状腺激素样化合物是与 TRα 或 TRβ 结合的化学实体，其解离常数 Kd 低于 1µM，其中 Kd = [R] - [L] / [RL]，其中 [R] 是受体的浓度，[L] 是配体的浓度，[RL] 是受体-配体复合物的浓度；至少一种选自维生素 D、糖皮质激素、维甲酸和维甲酸受体结合化合物或其类似物的成 分；以及药理学上可接受的碱。
• CMP slurry composition for metal wiring and polishing method using the same
  申请人：SAMSUNG SDI CO., LTD.

  公开号：US10100225B2

  公开（公告）日：2018-10-16

  A CMP slurry composition for polishing a metal wire and a polishing method, the CMP slurry composition including polishing particles; an oxidant; a complexing agent; a corrosion inhibitor; and deionized water, wherein the corrosion inhibitor includes an inorganic nitrite or ammonium nitrate.

  一种用于抛光金属线材的 CMP 泥浆组合物和抛光方法，该 CMP 泥浆组合物包括抛光颗粒；氧化剂；络合剂；缓蚀剂；以及去离子水，其中缓蚀剂包括无机亚硝酸盐或硝酸铵。
• CMP slurry composition for polishing copper and polishing method using the same
  申请人：SAMSUNG SDI CO., LTD.

  公开号：US10150890B2

  公开（公告）日：2018-12-11

  Disclosed herein is a CMP slurry composition for polishing copper. The CMP slurry composition includes: polishing particles; and deionized water, wherein the polishing particles include inorganic particles and organic particles, and both the inorganic particles and the organic particles have a positive zeta potential. A polishing method comprising polishing a copper wire using the CMP slurry composition also be provided.

  本文公开了一种用于抛光铜的 CMP 泥浆组合物。该 CMP 泥浆组合物包括：抛光颗粒；去离子水，其中抛光颗粒包括无机颗粒和有机颗粒，且无机颗粒和有机颗粒均具有正 Zeta 电位。还提供了一种抛光方法，包括使用 CMP 泥浆组合物抛光铜线。
• Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds
  申请人：——

  公开号：US20020123521A1

  公开（公告）日：2002-09-05

  The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal atrophy of the skin, and comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base suitable for topical application, wherein the thyroid hormone compound or the thyroid hormone-like compound binds to TR-&agr; or TR-&bgr; with an equilibrium dissociation constant, K d , of at least 10 −5 M. The invention is also directed to an article of manufacture comprising packaging material and a pharmaceutical agent contained within the packaging material, wherein the pharmaceutical agent is therapeutically effective for treating dermal atrophy of the skin.

  本发明涉及一种治疗皮肤真皮萎缩的方法。本发明的方法包括在患有皮肤真皮萎缩的哺乳动物的皮肤上施用一种组合物，该组合物包含至少一种甲状腺激素化合物或甲状腺激素样化合物以及适合局部施用的药理学上可接受的基质，其中甲状腺激素化合物或甲状腺激素样化合物与TR-&agr;或TR-&bgr;结合，其平衡解离常数K d 至少为 10 -5 M.本发明还涉及一种制造品，包括包装材料和包含在包装材料中的药剂，其中药剂对治疗皮肤真皮萎缩具有治疗效果。
• Dermatological formulations
  申请人：——

  公开号：US20040234592A1

  公开（公告）日：2004-11-25

  A composition comprising at least one thyroid hormone compound or thyroid hormone-like compound, a hydrophilic phase-forming component, an amino alcohol and at least two emulsifying or emollient excipients selected from the group consisting of mineral oil, C 12 -C 24 alcohols, C 12 -C 24 carboxylic acids, C 1 -C 8 branched or linear alkyl esters of C 12 -C 24 carboxylic acids, glyceryl esters of C 12 -C 24 carboxylic acids, macrogel ethers, polyethylene glycol esters of C 12 -C 24 carboxylic acids, sorbitan esters of C 12 -C 24 carboxylic acids (Span compounds) and polyoxyethylenated sorbitan esters of C 12 -C 24 carboxylic acids (Tween compounds). A preferred thyroid hormone or thyroid hormone-like compound is triiodothyroacetic acid (TriAc; 4-(4-hydroxy-3-iodophenoxy-3,5-diiodophenyl)acetic acid) and a preferred amino alcohol is triethanolamine.

  一种组合物，包含至少一种甲状腺激素化合物或甲状腺激素样化合物、一种亲水成相成分、一种氨基醇和至少两种乳化或润肤赋形剂，这两种赋形剂选自矿物油、C 12 -C 24 醇、C 12 -C 24 羧酸，C 1 -C 8 的支链或直链烷基酯 12 -C 24 羧酸的甘油酯、C 12 -C 24 羧酸、大凝胶醚、C 12 -C 24 的聚乙二醇酯 12 -C 24 羧酸、C-12-C-24 的山梨糖醇酯 12 -C 24 羧酸的山梨醇酯（斯潘化合物）和聚氧乙烯山梨醇酯（C 12 -C 24 羧酸的聚氧乙烯山梨醇酯（吐温化合物）。优选的甲状腺激素或甲状腺激素样化合物是三碘甲状腺乙酸（TriAc；4-（4-羟基-3-碘苯氧基-3,5-二碘苯基）乙酸），优选的氨基醇是三乙醇胺。