L-Arginine dihydrochloride | 58107-60-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Arginine dihydrochloride
• 英文别名: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;dihydrochloride
• CAS: 58107-60-1
• 化学式: C6H16Cl2N4O2
• 分子量: 247.12
• InChiKey: CIFDKEOHAJGWGZ-FHNDMYTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  128
• 氢给体数：
  6
• 氢受体数：
  4

文献信息

• Use of L-Carnitine, salts and derivatives thereof for reducing or preventing fatigue and improving cognitive function
  申请人：Lonza Ltd

  公开号：EP2508179A1

  公开（公告）日：2012-10-10

  The invention relates to the use of L-carnitine, a salt of L-carnitine, a derivative of L-carnitine and/or salt of a derivative of L-carnitine, as well as respective methods and compositions, for reducing or preventing fatigue and/or for improving cognitive function in an animal. The animal is preferably a healthy individual and the use is preferably a non-therapeutic use.

  本发明涉及使用左旋肉碱、左旋肉碱盐、左旋肉碱衍生物和/或左旋肉碱衍生物盐，以及相应的方法和组合物，用于减轻或预防动物的疲劳和/或改善认知功能。该动物最好是健康个体，使用最好是非治疗性使用。
• PEPTIDE SUBSTANCE STIMULATING REGENERATION OF CENTRAL NERVOUS SYSTEM NEURONS, PHARMACEUTICAL COMPOSITION ON ITS BASE, AND THE METHOD OF ITS APPLICATION
  申请人：Khavinson Vladimir Khatskelevich

  公开号：US20090105157A1

  公开（公告）日：2009-04-23

  The invention is related to the medicinal means of treatment of diseases, traumas, as well as consequences of traumas of the central nervous system, and can be also used as a means of stimulating neurons regeneration. There is proposed a peptide glutamyl-aspartyl-arginine with general formula H-GIu-Asp-Arg-OH sequence 1 [SEQ ID NO:1] capable of stimulating the regeneration of neurons. There is also proposed a pharmaceutical composition stimulating the regeneration of neurons containing peptide glutamyl-aspartyl-arginine with general formula H-GIu-Asp-Arg-OH sequence 1 [SEQ ID NO:1] as its active base, as well as a pharmaceutically acceptable carrier. There is proposed a method of stimulating the regeneration of neurons consisting in the administration to a patient of the pharmaceutical composition, containing peptide glutamyl-aspartyl-arginine with general formula H-Glu-Asp-Arg-OH sequence 1 [SEQ ID NO:1] as its active base, in the dose of 0.01-100 μg/kg of body weight at least once a day during a period necessary for attaining the therapeutic effect, such administration being performed parenterally.

  该发明涉及治疗疾病、创伤以及中枢神经系统创伤后遗症的药物治疗手段，同时也可以作为刺激神经元再生的手段。提出了一种具有通用公式H-GIu-Asp-Arg-OH序列1 [SEQ ID NO：1]的肽谷氨酰天冬氨酸-精氨酸，能够刺激神经元再生。还提出了一种刺激神经元再生的药物组合物，其中包含具有通用公式H-GIu-Asp-Arg-OH序列1 [SEQ ID NO：1]作为其活性基础的肽谷氨酰天冬氨酸-精氨酸，以及药学上可接受的载体。提出了一种刺激神经元再生的方法，包括向患者注射药物组合物，该组合物包含具有通用公式H-Glu-Asp-Arg-OH序列1 [SEQ ID NO：1]作为其活性基础的肽谷氨酰天冬氨酸-精氨酸，剂量为0.01-100 μg / kg体重，每天至少一次，直到达到治疗效果所需的期间，此类注射是经过家长eral途径进行的。
• Medical article
  申请人：The BOC Group plc

  公开号：EP0818207A2

  公开（公告）日：1998-01-14

  A medical article, particularly a central venous catheter, releasably incorporates a first therapeutically acceptable antibacterial agent comprising a quaternary ammonium compound other than a quaternary ammonium salt of an amino acid or other amine substituted organic acid and a second therapeutically acceptable antibacterial agent comprising an amino acid or other amine substituted organic acid or an acid addition salt of the amino acid or the other amine substituted organic acid. The first antibacterial agent is preferably benzalkonium chloride and the second antibacterial agent is preferably L-arginine or L-arginine hydrochloride.

  一种医疗用品，特别是中心静脉导管，可释放地含有第一种治疗上可接受的抗菌剂，包括氨基酸或其他胺取代的有机酸的季铵盐以外的季铵化合物，以及第二种治疗上可接受的抗菌剂，包括氨基酸或其他胺取代的有机酸或氨基酸或其他胺取代的有机酸的酸加成盐。第一种抗菌剂最好是苯扎氯铵，第二种抗菌剂最好是 L-精氨酸或 L-精氨酸盐酸盐。
• Use of L-carnitine, salts and derivatives thereof for reducing or preventing fatigue and improving cognitive function
  申请人：Williams Adriana

  公开号：US10130602B2

  公开（公告）日：2018-11-20

  The invention relates to the use of L-carnitine, a salt of L-carnitine, a derivative of L-carnitine and/or salt of a derivative of L-carnitine, as well as respective methods and compositions, for reducing or preventing fatigue and/or for improving cognitive function in an animal. The animal is preferably a healthy individual and the use is preferably a non-therapeutic use.

  本发明涉及左旋肉碱、左旋肉碱的盐、左旋肉碱的衍生物和/或左旋肉碱衍生物的盐，以及相应的方法和组合物，用于减轻或预防动物的疲劳和/或改善动物的认知功能。动物最好是健康个体，用途最好是非治疗性用途。
• Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
  申请人：Durect Corporation

  公开号：US10758623B2

  公开（公告）日：2020-09-01

  The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

  本公开一般提供包括药物活性剂和官能化聚合物的复合物，其中官能化聚合物包括重复单元，重复单元包括具有至少一个可电离侧基和/或可电离端基的可电离重复单元，多个至少一个可电离基团与药物活性剂形成非共价键。此外，还提供了可用于形成此类复合物的聚合物，以及制造和使用复合物及相关组合物的方法。