2-[Bis(carboxylatomethyl)amino]acetate;cadmium(2+);hydron | 49784-44-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[Bis(carboxylatomethyl)amino]acetate;cadmium(2+);hydron
• 英文别名: 2-[bis(carboxylatomethyl)amino]acetate;cadmium(2+);hydron
• CAS: 49784-44-3
• 化学式: C6H7CdNO6
• 分子量: 301.54
• InChiKey: ANTJAOCZNGADFY-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.13
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

毒理性

• 致癌性证据

评估：有足够的人类证据表明镉及其化合物具有致癌性。有足够的实验动物证据表明镉化合物具有致癌性。对于镉金属的致癌性，实验动物中提供的证据有限。在做出整体评估时，工作组考虑到了证据，即离子镉会在包括人类细胞在内的各种真核细胞中引起遗传毒性效应。总体评估：镉及其化合物对人类具有致癌性（第1组）。/镉及其化合物/

Evaluation: There is sufficient evidence in humans for the carcinogenicity of cadmium and cadmium compounds. There is sufficient evidence in experimental animals for the carcinogenicity of cadmium compounds. There is limited evidence in experimental animals for the carcinogenicity of cadmium metal. In making the overall evaluation, the Working Group took into consideration the evidence that ionic cadmium causes genotoxic effects in a variety of types of eukaryotic cells, including human cells. Overall evaluation: Cadmium and cadmium compounds are carcinogenic to humans (Group 1). /Cadmium and cadmium compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：B1；可能的人类致癌物。分类依据：来自职业流行病学研究中的镉证据有限，但在调查者和研究人群之间是一致的。有充分的证据表明，在大鼠和小鼠中通过吸入、肌肉注射和皮下注射具有致癌性。在大鼠和小鼠中的七项研究中，口服镉盐（醋酸盐、硫酸盐、氯化物）没有显示出致癌反应的证据。人类致癌性数据：有限。/根据前美国环保署指南进行的分类/

CLASSIFICATION: B1; probable human carcinogen. BASIS FOR CLASSIFICATION: Limited evidence from occupational epidemiologic studies of cadmium is consistent across investigators and study populations. There is sufficient evidence of carcinogenicity in rats and mice by inhalation and intramuscular and subcutaneous injection. Seven studies in rats and mice wherein cadmium salts (acetate, sulfate, chloride) were administered orally have shown no evidence of carcinogenic response. HUMAN CARCINOGENICITY DATA: Limited. /Classification based on former EPA guidelines/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A2；可疑的人类致癌物。/镉及其化合物，如Cd/

A2; Suspected human carcinogen. /Cadmium and compounds, as Cd/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

镉及镉化合物：已知的人类致癌物。

Cadmium and Cadmium Compounds: known to be human carcinogens.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

肾毒素 - 该化学品在职业环境中可能对肾脏有毒。 生殖毒素 - 对生殖系统有毒的化学品，包括对后代缺陷以及损伤男性或女性生殖功能。生殖毒性包括发育效应。参见生殖毒性风险评估指南。 IARC致癌物 - 3类：化学品无法被国际癌症研究机构分类。 NTP致癌物 - 有理由预期为人类致癌物。

Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting. Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment. IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer. NTP Carcinogen - Reasonably anticipated to be a human carcinogen.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

反应信息

• 作为产物：
  描述：

  氯化镉 、 次氮基三乙酸 生成 2-[Bis(carboxylatomethyl)amino]acetate;cadmium(2+);hydron
  参考文献：
  名称：

  AHLERS, JAN;ROSICK, ERIKA, BULL. ENVIRON. CONTAM. AND TOXICOL., 37,(1986) N 1, 96-105

  摘要：

  DOI：

文献信息

• AHLERS, JAN;ROSICK, ERIKA, BULL. ENVIRON. CONTAM. AND TOXICOL., 37,(1986) N 1, 96-105
  作者：AHLERS, JAN、ROSICK, ERIKA

  DOI：——

  日期：——