R-1-1H-3-苄氧基吡咯烷盐酸盐 | 927819-90-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: R-1-1H-3-苄氧基吡咯烷盐酸盐
• 中文别名: R-1-1氢-3-苄氧基吡咯烷盐酸盐；(R)-3-苄氧基吡咯烷盐酸盐
• 英文名称: (R)-3-(benzyloxy)pyrrolidine hydrochloride
• 英文别名: (R)-3-Benzyloxypyrrolidine hydrochloride；(3R)-3-phenylmethoxypyrrolidine;hydrochloride
• CAS: 927819-90-7
• 化学式: C₁₁H₁₅NO*ClH
• 分子量: 213.707
• InChiKey: HIPRPABXTKKPPY-RFVHGSKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  R-1-1H-3-苄氧基吡咯烷盐酸盐 在 sodium hydroxide 作用下， 以 水 、 乙酸乙酯 为溶剂， 生成 3-苄氧基吡咯烷
  参考文献：
  名称：

  PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE

  摘要：

  公开号：

  EP1947083B1
• 作为产物：
  描述：

  3-苄氧基吡咯烷 在 盐酸 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 1.0h， 以75.1%的产率得到R-1-1H-3-苄氧基吡咯烷盐酸盐
  参考文献：
  名称：

  PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE

  摘要：

  公开号：

  EP1950198B1

文献信息

• [EN] 2,8-DIACYL-2,8-DIAZASPIRO[5.5]UNDECANE COMPOUNDS USEFUL AS IMMUNOMODULATORS<br/>[FR] COMPOSÉS 2,8-DIACYLE -2,8-DIAZASPIRO [5,5] UNDÉCANE UTILES COMME IMMUNOMODULATEURS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2019147662A1

  公开（公告）日：2019-08-01

  The present disclosure generally relates to compounds of formula (I) useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

  本公开涉及通式（I）化合物，其作为免疫调节剂有用。本公开提供了包括该类化合物的化合物、组合物以及使用它们的方法。本公开进一步涉及包括至少一种根据本公开的化合物的制药组合物，其对于治疗各种疾病，包括癌症和传染病有用。
• Carboxamide derivatives as muscarinic receptor antagonists
  申请人：Glossop Alan Paul

  公开号：US20070105831A1

  公开（公告）日：2007-05-10

  The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.

  本发明涉及具有下列公式的化合物、其制备方法和中间体，以及包含它们的抗胆碱能药物组合物。
• Carboxamide Derivatives As Muscarinic Receptor Antagonists
  申请人：Glossop Paul Alan

  公开号：US20100029720A1

  公开（公告）日：2010-02-04

  The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.

  本发明涉及具有以下式的化合物，以及制备它们的过程和中间体，它们作为毒蕈碱受体拮抗剂的用途和包含它们的制药组合物。
• Process for Production of Benzyloxypyrrolidine Derivative, and Process for Production of Hydrochloride Salt Powder of Optically Active Benzyloxypyrrolidine Derivative
  申请人：Morimoto Masao

  公开号：US20090093643A1

  公开（公告）日：2009-04-09

  Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in high yield and safety; the process for production of a benzyloxypyrrolidine derivative expressed by the general formula (2) [Chemical formula 2], in reacting a pyrrolidinol derivative represented by the general formula (1) [Chemical formula 1] with a benzyl halide derivative in the presence of an alkali metal hydroxide, wherein the reaction is carried out in either of the following conditions A or B; condition A: an aprotic polar solvent, and condition B: an aliphatic ether solvent containing a phase transfer catalyst:

  提供了一种高产率和安全性的苯甲氧吡咯烷衍生物的生产工艺，以及一种高产率和安全性的苯甲氧吡咯烷衍生物盐酸盐粉末的生产工艺。苯甲氧吡咯烷衍生物的生产工艺由化学式（2）[化学式2]表示，通过在碱金属氢氧化物存在下，用苯甲醇衍生物与苯甲基卤代物反应，反应条件为以下条件A或B之一：条件A为无极性极性溶剂，条件B为含有相转移催化剂的脂肪醚溶剂。
• Process For Production of Aralkyloxypyrrolidine Derivative
  申请人：Takeda Toshihiro

  公开号：US20080306283A1

  公开（公告）日：2008-12-11

  The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aralkyloxypyrrolidine by allowing an aralkyl halide to act in the presence of a base and at least one of a metal halide and a phase-transfer catalyst followed by deprotecting a N-protecting group to convert it to a 3-aralkyloxypyrrolidine derivative and subsequently treating the derivative in a solvent containing a polar solvent, thereby obtaining the 3-aralkyloxypyrrolidine derivative as a crystal. According to the present invention, a 3-aralkyloxypyrrolidine derivative of high purity can be produced conveniently and efficiently on an industrial scale.

  本发明提供了一种生产3-芳基氧基吡咯烷衍生物的方法，该方法对于制药产品的生产等非常重要。在本发明中，将N-保护-3-羟基吡咯烷转化为N-保护-3-芳基氧基吡咯烷，通过在碱和至少一个金属卤化物和相转移催化剂的存在下使芳基卤化物起作用，然后去保护N-保护基，将其转化为3-芳基氧基吡咯烷衍生物，随后在含有极性溶剂的溶剂中处理该衍生物，从而得到3-芳基氧基吡咯烷衍生物的晶体。根据本发明，可以在工业规模上方便高效地生产高纯度的3-芳基氧基吡咯烷衍生物。