isobutyl-methyl-malonic acid diethyl ester | 58447-70-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: isobutyl-methyl-malonic acid diethyl ester
• 英文别名: Isobutyl-methyl-malonsaeure-diaethylester；Diethyl methyl(2-methylpropyl)propanedioate；diethyl 2-methyl-2-(2-methylpropyl)propanedioate
• CAS: 58447-70-4
• 化学式: C₁₂H₂₂O₄
• 分子量: 230.304
• InChiKey: XFWVBNMJPCASCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  isobutyl-methyl-malonic acid diethyl ester 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 48.0h， 以58%的产率得到
  参考文献：
  名称：

  Bis-Substituted Malonic Acid Hydroxamate Derivatives as Inhibitors of Human Neutrophil Collagenase (MMP8)

  摘要：

  Malonic acid hydroxamate derivatives bis-substituted at the methylene group were synthesized as potential nonpeptidic inhibitors of human neutrophil collagenase (MMP8). The presence of an aromatic residue both at the C2 malonic acid position and in the C-terminal tail for hydrophobic interactions with the surface-exposed S1 binding site and the S1' pocket of the enzyme, respectively, was found to be sufficient for submicromolar inhibition potencies. For optimal insertion of the aryl amide group into the hydrophobic S1' pocket, spacing of the C-terminal phenyl group by at least a SC-chain was required. In view of these results the achiral indan-2,2-dicarboxylic acid was used to mimic the 2-benzyl-2-methylmalonic acid residue, and its derivatization to the 3-phenylpropyl amide hydroxamate produced a potent, achiral, low-mass inhibitor of MMP8 (K-i = 0.3 mu M), the binding mode of which was unambiguously determined by X-ray crystallographic analysis.

  DOI：

  10.1021/jm980112p
• 作为产物：
  描述：

  异丁基丙二酸二乙酯 、 sodium ethanolate 、 碘甲烷 生成 isobutyl-methyl-malonic acid diethyl ester
  参考文献：
  名称：

  Sommaire, Bulletin de la Societe Chimique de France, 1923, vol. <4> 33, p. 195

  摘要：

  DOI：

文献信息

• Olefin polymerization catalyst components and process for the production of olefin polymers therewith
  申请人：Formosa Plastics Corporation

  公开号：US10124324B1

  公开（公告）日：2018-11-13

  The present invention relates to a Ziegler-Natta catalyst component for olefin polymerization containing an amide element in combination with one or more internal electron donors. The catalyst components, according to the present invention, are able to produce polypropylene polymers with higher stereo-regularity. The present invention also provides a phthalate-free catalyst system capable of producing polypropylene with an isotacticity that is equal to or higher than catalyst systems containing phthalate derivatives.

  本发明涉及一种用于烯烃聚合的齐格勒-纳塔催化剂组分，该组分含有酰胺元素，并与一个或多个内部电子供体相结合。根据本发明，催化剂组分能够生产出立体规整度更高的聚丙烯聚合物。本发明还提供了一种不含邻苯二甲酸酯的催化剂体系，能够生产出等同或高于含有邻苯二甲酸酯衍生物的催化剂体系的聚丙烯。
• Components and catalysts for the polymerization of olefins
  申请人：——

  公开号：US20040048738A1

  公开（公告）日：2004-03-11

  Catalyst component for the polymerization of olefins obtainable by contacting: (i) a magnesium halide, or a suitable precursor; (ii) a monofunctional electron donor compound (MD) selected from ethers, esters, amines or ketones, used in such amounts to have Mg/MD molar ratios of at least 50; (iii) a titanium compound of formula Ti(ORI)n-yXy, where n is the valence of titanium, y is a number between 1 and n, X is halogen, and RI is a C1-C15 hydrocarbon group and, optionally, (iv) an electron donor compound (ED). The said catalyst component shows improved activity in the polymerization of olefins.

  用于烯烃聚合的催化剂组分，可通过以下方式获得(i) 卤化镁或合适的前体；(ii) 选自醚、酯、胺或酮的单官能团电子供体化合物 (MD)，其用量应使 Mg/MD 摩尔比至少为 50；(iii) 式 Ti(ORI)n-yXy 的钛化合物，其中 n 是钛的价，y 是介于 1 和 n 之间的数字，X 是卤素，RI 是 C1-C15 烃基，以及 (iv) 电子供体化合物 (ED)。上述催化剂组分在烯烃聚合中显示出更高的活性。
• LONG-LIVED HOMOGENOUS OXIDATION CATALYSTS
  申请人：CARNEGIE MELLON UNIVERSITY

  公开号：EP0914206B1

  公开（公告）日：2002-12-11
• COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS
  申请人：Montell Technology Company bv

  公开号：EP0920461A1

  公开（公告）日：1999-06-09
• CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS
  申请人：Basell Poliolefine Italia S.p.A.

  公开号：EP0994905B1

  公开（公告）日：2004-01-21