(1Z)-1-indol-3-ylidene-N-methylmethanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (1Z)-1-indol-3-ylidene-N-methylmethanamine
• 化学式: C₁₀H₁₀N₂
• 分子量: 158.2
• InChiKey: KNNTXMISVUAXHB-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] COMBINED PIKFYVE AND P38 MAP KINASE INHIBITION FOR TREATING CANCER<br/>[FR] INHIBITION COMBINÉE DE PIKFYVE ET DE KINASE MAP P38 POUR LE TRAITEMENT DU CANCER
  申请人：US HEALTH

  公开号：WO2021086912A1

  公开（公告）日：2021-05-06

  Disclosed is a method for treating a cancer in a mammal in need thereof, comprising administering to the mammal a combination of effective amount of an autophagy inhibitor and a p38 mitogen-activated protein kinase (p38 MAPK) inhibitor, wherein the effective amount is sufficient to reduce or inhibit proliferation of cancer cells or to cause the death of cancer cells.
• [EN] THERAPEUTICS AGAINST PATHOGENIC CORONAVIRUSES<br/>[FR] AGENTS THÉRAPEUTIQUES DIRIGÉS CONTRE LES CORONAVIRUS PATHOGÈNES
  申请人：[en]THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：WO2022115327A1

  公开（公告）日：2022-06-02

  Compounds for use in treating a coronavirus infection in a subject, particularly an infection caused by SARS-CoV-2, SARS-CoV or MER-CoV.