2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-6-carboximidamide | 65426-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-6-carboximidamide
• CAS: 65426-89-3
• 化学式: C₂₂H₁₉N₅O
• 分子量: 369.4
• InChiKey: OSSYTOVYXCAWPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  5
• 氢受体数：
  3

文献信息

• Visual function disorder improving agents
  申请人：——

  公开号：US20040106646A1

  公开（公告）日：2004-06-03

  The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-( 1 H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.

  本发明提供了一种含有具有Rho激酶抑制活性的化合物的视觉功能障碍改善剂，特别是(R)-(+)-N-(1H-吡咯[2,3-b]吡啶-4-基)-4-(1-氨基乙基)苯甲酰胺作为有效成分。该剂具有促进视网膜神经节细胞轴突延伸和视神经细胞再生的作用，可用于治疗与视网膜或视神经的损伤、缺陷、退化等引起的各种眼部疾病相关的视觉功能障碍。
• VISUAL FUNCTION IMPROVING AGENTS
  申请人：Senju Pharmaceutical Co., Ltd.

  公开号：EP1378247A1

  公开（公告）日：2004-01-07

  The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.

  本发明提供了一种视功能紊乱改善剂，其有效成分含有具有 Rho 激酶抑制活性的化合物，特别是(R)-(+)-N-(1H-吡咯并[2,3-b]吡啶-4-基)-4-(1-氨基乙基)苯甲酰胺。这种药剂具有促进视网膜神经节细胞轴突延伸的作用和促进视神经细胞再生的作用，可用于治疗因视网膜或视神经系统损伤、缺损、变性等引起的与各种眼病相关的视觉功能障碍。
• VISUAL FUNCTION DISORDER IMPROVING AGENTS
  申请人：Senju Pharmaceutical Co., Ltd.

  公开号：EP1378247B1

  公开（公告）日：2016-08-24
• BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS
  申请人：United States Government As Represented By The Secretary of The United States Army And The U.S. Army Medical Research & Materiel Command

  公开号：EP1945209B1

  公开（公告）日：2018-05-30
• Small Molecule Inhibitors of Botulinum Neurotoxins
  申请人：Bavari Sina

  公开号：US20070112049A1

  公开（公告）日：2007-05-17

  Disclosed herein are methods of inhibiting the activity of Botulinum neurotoxin A metalloprotease with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or preventing intoxication caused by bacteria of at least one bacterial strain in a subject, and pharmaceutical and cosmetic compositions comprising the compounds disclosed herein.