N-Dodecyl-N-(2-methoxyethyl)acetamide | 157843-51-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Dodecyl-N-(2-methoxyethyl)acetamide
• CAS: 157843-51-1
• 化学式: C₁₇H₃₅NO₂
• 分子量: 285.5
• InChiKey: ARINIYWVBQSCPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Delivery of drug nanoparticles and methods of use thereof
  申请人：DFB Soria, LLC

  公开号：US10449162B2

  公开（公告）日：2019-10-22

  Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.

  所公开的是用于增强药物纳米粒子皮肤渗透性的组合物和方法。这些组合物可以是疏水性的，包括疏水载体、挥发性硅油和药物纳米粒子。还公开了在水性载体或疏水性载体中抑制药物纳米粒子晶体生长的方法。此外，还公开了使用含有紫杉醇或其他类固醇的纳米颗粒的组合物局部治疗牛皮癣的方法。
• Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes
  申请人：DFB SORIA, LLC

  公开号：US10555898B2

  公开（公告）日：2020-02-11

  Disclosed are methods useful for the topical therapeutic treatment of skin malignancies including skin cancers and cutaneous metastases using compositions containing nanoparticles of paclitaxel or other taxanes.

  公开了使用含有紫杉醇或其他类固醇纳米颗粒的组合物局部治疗皮肤恶性肿瘤（包括皮肤癌和皮肤转移瘤）的方法。
• Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
  申请人：CRITITECH, INC.

  公开号：US11058639B2

  公开（公告）日：2021-07-13

  Disclosed are combination therapy methods useful for the therapeutic treatment of cancer by combining local administration of compositions containing antineoplastic particles, such as taxane particles, with systemic administration of compositions containing immunotherapeutic agents. Local administration methods include topical application, pulmonary administration, intratumoral injection, intraperitoneal injection, and intracystic injection.

  所公开的是通过将局部给药含有抗肿瘤微粒（如紫杉烷微粒）的组合物与全身给药含有免疫治疗剂的组合物相结合来治疗癌症的组合治疗方法。局部给药方法包括局部应用、肺部给药、瘤内注射、腹膜内注射和囊内注射。
• APPARATUS AND METHODS FOR EVALUATING THE BARRIER PROPERTIES OF A MEMBRANE
  申请人：Fqubed, Inc.

  公开号：EP1680223A2

  公开（公告）日：2006-07-19
• EP1680223A4
  申请人：——

  公开号：EP1680223A4

  公开（公告）日：2008-07-09