tetra O-acetyl-2,3,4,6 -1-desoxy-1-D-glucopyranose | 74427-64-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetra O-acetyl-2,3,4,6 -1-desoxy-1-D-glucopyranose
• 英文别名: D-1-Deoxy-1-(bis(2-chloroethyl)amino)-2,3,4,6-O-tetraacetylglucopyranose；[(2R,3R,4S,5R)-3,4,5-triacetyloxy-6-[bis(2-chloroethyl)amino]oxan-2-yl]methyl acetate
• CAS: 74427-64-8
• 化学式: C₁₈H₂₇Cl₂NO₉
• 分子量: 472.32
• InChiKey: DJUWKQJNJVMFIU-IHAUNJBESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  乙酸酐 、 -1-desoxy-1-D-glucopyranose 在 吡啶 作用下， 以87%的产率得到tetra O-acetyl-2,3,4,6 -1-desoxy-1-D-glucopyranose
  参考文献：
  名称：

  Moruzzi; Montero; Imbach, European Journal of Medicinal Chemistry, 1980, vol. 15, # 2, p. 125 - 132

  摘要：

  DOI：

文献信息

• USE OF DIANHYDROGALACTITOL AND DERIVATIVES THEREOF IN THE TREATMENT OF GLIOBLASTOMA, LUNG CANCER, AND OVARIAN CANCER
  申请人：Bacha Jeffrey A.

  公开号：US20190091195A1

  公开（公告）日：2019-03-28

  Substituted hexitol derivatives such as dianhydrogalactitol are useful in the treatment of various neoplastic pathologies. Said pathologies include glioblastoma multiforme, non-small-cell lung carcinoma (NSCLC), ovarian cancer, and leptomeningeal carcinomatosis. The anti-neoplastic activity of dianhydrogalactitol is demonstrated to be due to its activity as an alkylating agent that creates N 7 methylation and inter-strand DNA crosslinks. The hexitol derivatives may be used alone or in combination with other anti-neoplastic agents.
• Moruzzi; Montero; Imbach, European Journal of Medicinal Chemistry, 1980, vol. 15, # 2, p. 125 - 132
  作者：Moruzzi、Montero、Imbach

  DOI：——

  日期：——