Octadecanoic acid, hydroxy-, monoester with 1,2,3-propanetriol | 1323-42-8

• 物质功能分类: 表面活性剂 - 非离子表面活性剂 - 多元醇酯型
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Octadecanoic acid, hydroxy-, monoester with 1,2,3-propanetriol
• 英文别名: 1,3-dihydroxypropan-2-yl 2-hydroxyoctadecanoate
• CAS: 1323-42-8
• 化学式: C₂₁H₄₂O₅
• 分子量: 374.6
• InChiKey: YIDBZTKQBSDQDX-UHFFFAOYSA-N

物化性质

• 沸点：
  485℃[at 101 325 Pa]
• 密度：
  1.1[at 20℃]
• LogP：
  5.08 at 20℃

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  26
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Phenylcyclohexanol Derivatives As Wax Modifiers And Gelators
  申请人：XEROX CORPORATION

  公开号：US20140165873A1

  公开（公告）日：2014-06-19

  A compound of the formula wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are each independently selected from a member of the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkylaryl, straight-chain hydrocarbon, branched-chain hydrocarbon, halogen, and mixtures thereof; wherein X 1 , X 2 , X 3 , X 4 , and X 5 are each independently selected from a member of the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkylaryl, alkoxyl, aryloxy, straight-chain hydrocarbon, branched-chain hydrocarbon, halogen, and mixtures thereof; and wherein the compound can optionally be a mixture of cis and trans isomers wherein only one of R 1 to R 10 is a non-hydrogen group.

  其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10分别独立地选择自羟基、烷基、芳基、芳基烷基、烷基芳基、直链烃、支链烃、卤素和它们的混合物中的一种；其中X1、X2、X3、X4和X5分别独立地选择自羟基、烷基、芳基、芳基烷基、烷基芳基、烷氧基、芳氧基、直链烃、支链烃、卤素和它们的混合物中的一种；并且该化合物可以选择性地是顺式和反式异构体的混合物，其中仅有R1到R10中的一个是非氢基团。
• CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS FOR PROLONGED EFFECT
  申请人：Hemmingsen Pernille Hoyrup

  公开号：US20100239667A1

  公开（公告）日：2010-09-23

  Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part of the gastrointestinal tract. The composition comprising A) a solid inner layer comprising i) an active substance, and ii) one or more disintegrants/exploding agents, one of more effervescent agents or a mixture thereof. the solid inner layer being sandwiched between two outer layers B1) and B2), each outer layer comprising iii) a substantially water soluble and/or crystalline polymer or a mixture of substantially water soluble and/or crystalline polymers, the polymer being a polyglycol in the form of one of a) a homopolymer having a MW of at least about 100,000 daltons, and b) a copolymer having a MW of at least about 2,000 daltons, or a mixture thereof, and iv) an active substance, which is the same as in said solid inner layer A), and layer A being different from layer B, the layered composition being coated with a coating C) that has at least one opening exposing at least one surface of said outer layer, the coating being substantially insoluble in and impermeable to fluids and comprising a polymer, and the composition having a cylindrical form optionally with one or more tapered ends, wherein the ratio between the surface area of one end surface of the cylinder and the length of the cylinder is in a range of from 0.02 to 45 mm.

  分层制药组合物，适用于口服治疗吸收发生在胃肠道大部分的疾病。该组合物包括A) 一个固体内层，其中包括i) 一种活性物质，和ii) 一种或多种分散剂/爆炸剂，一种或多种泡腾剂或其混合物。该固体内层被夹在两个外层B1)和B2)之间，每个外层包括iii) 一种或多种水溶性和/或结晶聚合物，或者水溶性和/或结晶聚合物的混合物，聚合物为聚乙二醇，形式为a) 分子量至少为约100,000道尔顿的同聚物，和b) 分子量至少为约2,000道尔顿的共聚物，或其混合物，和iv) 一种活性物质，其与所述固体内层A)中的活性物质相同，且层A与层B不同，该分层组合物被涂覆有一种涂层C)，该涂层具有至少一个开口，暴露出至少一个外层的表面，该涂层在液体中具有相当的不溶性和不透性，包括一种聚合物，该组合物具有圆柱形状，可选地具有一个或多个锥形端部，其中圆柱体的一个端面的表面积与圆柱体的长度之比在0.02至45毫米的范围内。
• Production Of Inorganic-Organic Composite Materials By Reactive Spray-Drying
  申请人：BASF SE

  公开号：US20140228334A1

  公开（公告）日：2014-08-14

  Process for producing composite materials by reactive spray-drying, where a liquid phase A, which comprises inorganic cations, and a liquid phase B, which comprises anions which, with the inorganic cations, form a salt that is insoluble in the mixture of the liquid phases are sprayed together using at least one multi-substance nozzle, and where at least one hydrophobic active ingredient is present in dissolved form in at least one liquid spraying phase, and where the salt formed from the cations of phase A and the anions of phase B has a solubility of less than 0.02 mol/l in the neutral aqueous medium.

  使用反应性喷雾干燥制备复合材料的过程，其中液相A包含无机阳离子，液相B包含阴离子，与无机阳离子形成不溶于液相混合物的盐，两种液相使用至少一个多组分喷嘴同时喷射，至少一个疏水性活性成分以溶解形式存在于至少一种液体喷雾相中，由A相的阳离子和B相的阴离子形成的盐在中性水介质中的溶解度小于0.02mol/L。
• COMPOUNDS SUITABLE FOR USE IN INKS AND INKS HAVING SUCH COMPOUNDS
  申请人：BANNING Jeffrey H.

  公开号：US20090223409A1

  公开（公告）日：2009-09-10

  Disclosed herein are amide compounds suitable for use in ink compositions, and methods of making the amide compounds disclosed herein.

  本文披露了适用于油墨组合物的酰胺化合物，以及制备本文所披露的酰胺化合物的方法。
• Stabilized polyvinyl chloride resin composition
  申请人：KYOWA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0256872A2

  公开（公告）日：1988-02-24

  Magnesium oxide is incorporated into a polyvinyl chloride resin composition comprising a polyvinyl chloride, a hydrotalcite, a β-diketone compound and an organic acid salt of zinc or a polyvinyl chloride resin composition comprising a polyvinyl chloride, a hydro­talcite and an organic tin compound. Bubbling as well as discoloration can be prevented in a molded article prepared from the polyvinyl chloride resin composition. Magnesium oxide having a specific surface area of at least 50 m²/g and an average secondary particle size smaller than 5 µm is preferably used.

  将氧化镁加入由聚氯乙烯、氢铝酸盐、β-二酮化合物和锌的有机酸盐组成的聚氯乙烯树脂组合物中，或加入由聚氯乙烯、氢铝酸盐和有机锡化合物组成的聚氯乙烯树脂组合物中。用聚氯乙烯树脂组合物制备的模塑制品可以防止起泡和变色。最好使用比表面积至少为 50 m²/g、平均二次粒径小于 5 µm 的氧化镁。