(5Z)-5-(carbamoylhydrazinylidene)-1-methyl-6-oxo-2,3-dihydroindole-2-sulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (5Z)-5-(carbamoylhydrazinylidene)-1-methyl-6-oxo-2,3-dihydroindole-2-sulfonic acid
• 化学式: C₁₀H₁₂N₄O₅S
• 分子量: 300.29
• InChiKey: OZCACMPSTYQSMM-SDQBBNPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  151
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• Pharmaceutical composition and a method for enhancing the absorption of a pharmaceutically active compound
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0106335A2

  公开（公告）日：1984-04-25

  A pharmaceutical composition comprising a pharmaceutically active compound having an absolute bioavailability of not more than 20 % and diltiazem or a pharmaceutically acceptable acid addition salt thereof is disclosed. A method for enhancing the absorption of the pharmaceutically active compound by administering it enterally together with diltiazem or its salt is also disclosed. Diltiazem or its salt is effective to improve or enhance the absorption of said pharmaceutically active compound.

  本发明公开了一种药物组合物，该组合物包含生物利用度绝对值不超过 20% 的药用活性化合物和地尔硫卓或其药学上可接受的酸加成盐。本发明还公开了一种通过与地尔硫卓或其盐一起肠内给药来促进药用活性化合物吸收的方法。地尔硫卓或其盐可有效改善或促进上述药物活性化合物的吸收。
• US8232265B2
  申请人：——

  公开号：US8232265B2

  公开（公告）日：2012-07-31
• US8802596B2
  申请人：——

  公开号：US8802596B2

  公开（公告）日：2014-08-12