[(3-甲氧基-1-甲基-3-氧代丙-1-烯基)氨基]苯乙酸钾 | 67584-31-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: [(3-甲氧基-1-甲基-3-氧代丙-1-烯基)氨基]苯乙酸钾
• 英文名称: alpha-((3-Methoxy-1-methyl-3-oxo-1-propenyl)amino)benzeneacetic acid, monopotassium salt
• 英文别名: potassium;2-[[(E)-4-methoxy-4-oxobut-2-en-2-yl]amino]-2-phenylacetate
• CAS: 67584-31-0
• 化学式: C13H14KNO4
• 分子量: 287.35
• InChiKey: KBWPWSNLLTZFMR-HRNDJLQDSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.85
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a
  申请人：MERCK & CO INC

  公开号：WO2000006565A1

  公开（公告）日：2000-02-10

  This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

  本发明涉及某些新型化合物及其衍生物，它们的合成以及它们作为α1a肾上腺素能受体拮抗剂的用途。这些化合物的一个应用是治疗良性前列腺增生症。这些化合物在其选择性上具有放松充满α1a受体亚型的平滑肌组织的能力，而不会同时引起低血压。这样的组织可以在尿道内膜周围发现。因此，这些化合物的一个用途是为男性良性前列腺增生症提供急性缓解，从而使尿液流动更加顺畅。这些化合物的另一个用途是与人类5α-还原酶抑制剂化合物结合，从而实现对良性前列腺增生症的急性和慢性缓解。
• Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
  申请人：PFIZER INC.

  公开号：EP0108545A1

  公开（公告）日：1984-05-16

  A process for the preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate which comprises reacting 1,1-dioxopenicillanoyloxymethyl 6-phenylacetamidopenicillante or the corresponding phenoxy- acetamidopenicillanate under anhydrous conditions with a halogenating agent in the presence of a reaction inert solvent to form an intermediate imino halide, addition of a primary alcohol having from one to four carbon atoms to convert the imino halide to an imino ether and subsequent hydrolysis to give the desired product.

  1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate 的制备工艺，包括 1,1-dioxopenicillanoyloxymethyl 6-phenylacetamidopenicillante 或相应的 phenoxy- acetamidopenicillanate 在无水条件下，在反应惰性溶剂存在下与卤化剂反应，形成中间亚氨基卤化物、加入具有一至四个碳原子的伯醇，将亚胺卤化物转化为亚胺醚，然后水解得到所需的产品。
• Process for the preparation of the 1'-ethoxycarbonyloxyethyl ester of benzylpenicillin
  申请人：ASTRA LAKEMEDEL AKTIEBOLAG

  公开号：EP0108547A2

  公开（公告）日：1984-05-16

  The invention provides compounds of the general formula wherein X is -Cl, Br or -OCH2CH3, and the preparation thereof. One such compound, 1-bromoethyl ethyl carbonate, is useful as an esterification agent, e.g. for penicillins, and the other such compounds are intermediates in its preparation. The manufacture of formulations containing 1 '-ethoxycarbonyloxy ethyl esters of penicillins is included in the invention. There are also provided novel compounds of the formula in which Ph is phenyl and R is CH3- or C2H6-.

  本发明提供通式为 其中 X 为 -Cl、Br 或 -OCH2 的化合物及其制备方法。其中一种化合物，1-溴乙基碳酸酯，可用作酯化剂，例如青霉素类的酯化剂，其他此类化合物是其制备过程中的中间体。本发明包括生产含有青霉素 1'-乙氧基羰基乙基酯的制剂。 本发明还提供了式如下的新型化合物 其中 Ph 为苯基，R 为 CH3- 或 C2H6-。
• Intermediates in cephalosporin production
  申请人：——

  公开号：US20040192909A1

  公开（公告）日：2004-09-30

  A salt of PACA with an amidine and its use in the production of cefprozil.

  一种含脒的 PACA 盐及其在头孢丙烯生产中的应用。
• Improvements in or relating to beta lactam production
  申请人：BIOCHEMIE GESELLSCHAFT M.B.H.

  公开号：EP0439096B1

  公开（公告）日：2003-12-17