decanoic acid triethanolamine salt | 58793-73-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: decanoic acid triethanolamine salt
• 英文别名: triethanol ammonium decanoate；triethanolamine decanoate；Decanoate;tris(2-hydroxyethyl)azanium；decanoate;tris(2-hydroxyethyl)azanium
• CAS: 58793-73-0
• 化学式: C₆H₁₅NO₃*C₁₀H₂₀O₂
• 分子量: 321.458
• InChiKey: GKHDHUDIDOQOFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.48
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  101
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  三乙醇胺 、 正癸酸 反应 1.0h， 生成 decanoic acid triethanolamine salt
  参考文献：
  名称：

  新型生物基离子液晶的相行为和物理性质

  摘要：

  质子离子液体（PILs）以其易于制备和独特的性能而成为有前途的化合物，并引起了业界和学术界的关注。在绿色化学的背景下，使用生物化合物（例如脂肪酸）进行合成可能会公开一种可能的替代方法，以产生具有低毒性或无毒作用的IL，从而扩大其在生物基工艺或生物化学开发中的适用性。生物产品。这项工作致力于更好地理解通过使用植物油中常见的脂肪酸合成的20种新的PIL的固-[液晶]-液的复杂热力学平衡，以及它们的流变特性和自组装能力。这项工作表明，它们的相平衡和物理性质受到用于其合成的离子结构的显着影响。使用不饱和脂肪酸和双（2-羟乙基）铵合成这些生物基IL导致其熔融温度急剧降低。同样，最长的烷基链脂肪酸促进了更高的自组装和更稳定的中间相。除了具有可持续发展的吸引力外，此处公开的PIL晶体还具有明显的高粘度，非牛顿曲线和非常低的临界胶束浓度值，这使它们成为有趣的可再生化合物，具有作为乳化剂，稳定剂，增稠剂或生

  DOI：

  10.1021/acs.jpcb.7b01384

文献信息

• Composition for Patch Preparation Comprising Drug, Organic Solvent, Lipophilic Mass Base, and Powder
  申请人：MEDRX CO., LTD.

  公开号：US20150174249A1

  公开（公告）日：2015-06-25

  The present disclosure provides a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug.

  本公开提供了一种具有良好粘附性和可持续释放药物的非水性贴剂制剂组合物。通过添加粉末成分，该贴剂制剂可以改善贴剂制剂的粘附性和药物的释放性能，贴剂制剂的长时间粘附性能有助于提高经皮吸收性和药物的持续释放。
• ADHESIVE PREPARATION COMPOSITION OBTAINED BY BLENDING DRUG, ORGANIC SOLVENT, LIPOPHILIC OINTMENT BASE, AND POWDER
  申请人：Medrx Co., Ltd.

  公开号：EP2865376A1

  公开（公告）日：2015-04-29

  The object of the present invention is to provide a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation of the present invention can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient (a filler or the like). As a result, the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug. By the use of a composition for a patch preparation comprising this powder ingredient, a drug, regardless of the type of a drug is dissolved in an organic solvent or an ionic liquid to prepare a drug solution comprising the organic solvent, the drug solution is incorporated into the non-aqueous parch preparation of the present invention, and thereby a preparation with the improved transdermal absorbability and the improved sustained release can prepared.

  本发明的目的是提供一种可持续释放药物的非水贴剂组合物，该组合物具有极佳的粘附性。本发明的贴片制剂可以通过添加粉末成分（填料或类似物）来改善贴片制剂的粘附性和药物释放性能。因此，长期保持贴片制剂的粘附性可以提高药物的透皮吸收性和持续释放性。通过使用包含这种粉末成分的贴片制剂组合物，将药物（无论药物类型）溶解在有机溶剂或离子液体中，制备出包含有机溶剂的药物溶液，然后将药物溶液加入到本发明的非水基贴片制剂中，从而制备出具有改善的透皮吸收性和改善的持续释放性的制剂。
• NOVEL BASE COMPOSITION FOR TAPE AGENT
  申请人：MEDRx Co., Ltd.

  公开号：EP3045166A1

  公开（公告）日：2016-07-20

  The object of the present invention is to provide a composition for a non-aqueous patch preparation having an excellent adhesibility which can sustainedly release a drug. The patch preparation of the present invention can improve the adhesibility thereof as well as the release property of a drug by the addition of powder ingredient (e.g. a filler). As a result, the long-time sustention of the adhesibility of patch preparations can achieve the improvement of the transdermal absorbability and the sustained release of a drug. By the use of a composition for a patch preparation comprising this powder ingredient, a drug, regardless of the type of a drug is dissolved in an organic solvent or an ionic liquid to prepare a drug solution comprising the organic solvent, the drug solution is incorporated into the non-aqueous patch preparation of the present invention, and thereby a preparation with the improved transdermal-absorbability and sustained release can prepared.

  本发明的目的是提供一种用于非水贴剂制备的组合物，该组合物具有极佳的粘附性，可持续释放药物。 本发明的贴剂制剂可以通过添加粉末成分（如填充剂）来提高其粘附性以及药物释放性能。因此，长期保持贴片制剂的粘附性可以提高药物的透皮吸收性和持续释放性。通过使用包含这种粉末成分的贴剂制剂组合物，将药物（无论药物类型）溶解在有机溶剂或离子液体中，制备出包含有机溶剂的药物溶液，将药物溶液加入到本发明的非水贴剂制剂中，从而制备出具有改善的透皮吸收性和持续释放性的制剂。
• NOVEL COMPOSITION FOR PLASTER BASE MATERIAL IN TAPE PREPARATION
  申请人：MEDRx Co., Ltd.

  公开号：EP3824883A1

  公开（公告）日：2021-05-26

  The present invention relates to a composition for a non-aqueous patch preparation comprising a drug, an organic solvent, and a powder which is insoluble both in the organic solvent and in a lipophilic plaster base material, wherein the organic solvent comprises a fatty acid-based ionic liquid and/or a salicylic acid-based ionic liquid, the powder is light anhydrous silicic acid, and the powder for an adhesive layer is contained as shown in the following inequality: 0.2×the weight of the adhesive layer×the bulk density of the powder≤the amount of the powder to be added≤0.6×the weight of the adhesive layer×the tap density of the powder.

  本发明涉及一种用于非水贴剂制备的组合物，该组合物由药物、有机溶剂和既不溶于有机溶剂又不溶于亲脂性石膏基质材料的粉末组成，其中有机溶剂包括脂肪酸基离子液体和/或水杨酸基离子液体，粉末为轻质无水硅酸，用于粘合层的粉末的含有量如下不等式所示：0.2×粘合剂层的重量×粉末的体积密度≤粉末的添加量≤0.6×粘合剂层的重量×粉末的自重密度。
• Composition for patch preparation comprising drug, organic solvent, lipophilic mass base, and powder
  申请人：MEDRX CO., LTD.

  公开号：US10543275B2

  公开（公告）日：2020-01-28

  The present disclosure provides a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug.

  本公开提供了一种用于非水贴剂的组合物，该贴剂具有良好的粘附性，可持续释放药物。通过添加粉末成分，贴片制剂可以提高贴片制剂的粘附性和药物的释放性能，长期保持胶带制剂的粘附性可以提高药物的透皮吸收性和持续释放性。