4R-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1S-methanol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 4R-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1S-methanol
• 英文别名: [(1S)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol
• 化学式: C₁₄H₁₈N₆O
• 分子量: 286.33
• InChiKey: MCGSCOLBFJQGHM-HNHGDDPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Medicaments against viral diseases
  申请人：——

  公开号：US20030232842A1

  公开（公告）日：2003-12-18

  Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.

  新型二氢嘧啶和其他抗病毒药物的组合，适用于对抗HBV感染。
• Medicament for viral diseases
  申请人：——

  公开号：US20030187028A1

  公开（公告）日：2003-10-02

  Isoxazoles are highly effective anti-viral agents. Combinations of isoxazoles, dihydropyrimidines and/or lamivudine and, optionally, interferon inhibit the proliferation of HBV viruses better than conventional agents.

  异噁唑酮是高效的抗病毒药物。异噁唑酮、二氢嘧啶和/或拉米夫定以及可选的干扰素的组合，比传统药物更好地抑制HBV病毒的增殖。
• PROCESS FOR THE PREPARATION OF AMINO ALCOHOL DERIVATIVES OR SALTS THEREOF
  申请人：GRANULES INDIA LIMITED

  公开号：US20170233329A1

  公开（公告）日：2017-08-17

  The present invention relates to a process for the preparation of amino alcohol derivatives or salts thereof. In particular the present invention relates to process for the preparation of amino alcohol derivatives or salts thereof which may be used as intermediates in the preparation of HIV reverse transcriptase inhibitors, more preferably Carbovir and Abacavir. The present invention more specifically relates to a process for the preparation of (1S,4R)-4-amino-2-cyclopentene-1-methanol of Formula IIIa. The present invention also specifically relates to process for the preparation of Abacavir sulfate of Formula II using compound of Formula IIIa prepared according to the process of the present invention.

  本发明涉及一种用于制备氨基醇衍生物或其盐的方法。特别是，本发明涉及一种用于制备氨基醇衍生物或其盐的方法，该方法可用作制备HIV逆转录酶抑制剂的中间体，更具体地是卡波韦和阿巴卡韦。本发明更具体地涉及一种用于制备Formula IIIa的(1S,4R)-4-氨基-2-环戊烯-1-甲醇的方法。本发明还具体涉及一种使用根据本发明方法制备的Formula IIIa化合物制备Formula II的阿巴卡韦硫酸盐的方法。
• Medicaments for viral diseases
  申请人：——

  公开号：US20020082264A1

  公开（公告）日：2002-06-27

  Chromanone derivatives are highly active antiviral agents. Combinations of chromanones and/or chromanols with HBV polymerase inhibitors, HBV DNA inhibitors or HBV core protein inhibitors and/or isoxazoles and, where appropriate, interferon inhibit the replication of HBV viruses better than agents disclosed previously.

  Chromanone衍生物是高活性抗病毒剂。与HBV聚合酶抑制剂、HBV DNA抑制剂或HBV核蛋白抑制剂和/或异噁唑类化合物的组合以及必要时的干扰素能够比先前披露的药物更好地抑制HBV病毒的复制。
• Bromo-phenyl substituted thiazolyl dihydropyrimidines
  申请人：Sunshine Lake Pharma Co., Ltd

  公开号：EP2514750A1

  公开（公告）日：2012-10-24

  This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.

  本发明涉及一种溴苯基取代的噻唑基二氢嘧啶、其制备方法以及作为治疗和预防乙型肝炎感染药物的用途。本发明还涉及一种组合物，该组合物包含二氢嘧啶、一种或多种抗病毒剂，以及可选的免疫调节剂，用于治疗和预防 HBV 感染。