(6aS)-2-[2-[2-[[(6aS)-11-oxo-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-2-yl]oxy]ethyl-methylamino]ethoxy]-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one | 123064-64-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (6aS)-2-[2-[2-[[(6aS)-11-oxo-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-2-yl]oxy]ethyl-methylamino]ethoxy]-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• CAS: 123064-64-2
• 化学式: C₂₉H₃₃N₅O₄
• 分子量: 515.612
• InChiKey: VFWAHDYMKMHLAA-SFTDATJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  87
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  [5-[2-[2-[3-[(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl]-4-nitrophenoxy]ethyl-methylamino]ethoxy]-2-nitrophenyl]-[(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidin-1-yl]methanone 以40%的产率得到
  参考文献：
  名称：

  FARMER, J. DEAN;RUDNICKI, SUZANNE M.;SUGGS, J. WILLIAM, TETRAHEDRON LETT., 29,(1988) N 40, C. 5105-5108

  摘要：

  DOI：

文献信息

• Synthesis and dna crosslinking ability of a dimeric anthramycin analog
  作者：J.Dean Farmer、Suzanne M. Rudnicki、J. William Suggs

  DOI：10.1016/s0040-4039(00)80691-7

  日期：1988.1

  Linked analogs of the DNA binding antibiotic anthramycin are made via nucleophilic aromatic substitution followed by reduction-cyclization. The linked compounds protect DNA from restriction endonucleases and reversibly crosslink DNA.

  通过亲核芳族取代，然后还原环化，制备结合DNA的抗生素蒽霉素的连接类似物。连接的化合物可保护DNA不受限制性核酸内切酶的影响，并可逆地交联DNA。
• Enzymatic conjugation of polypeptides
  申请人：Innate Pharma

  公开号：US10434180B2

  公开（公告）日：2019-10-08

  The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.

  本申请涉及免疫球蛋白的酶功能化方法，特别是与药物的酶功能化。本文还公开了连接试剂、功能化抗体、药物组合物以及治疗疾病和/或病症的方法。
• NKp46 binding agents
  申请人：INNATE PHARMA

  公开号：US11377492B2

  公开（公告）日：2022-07-05

  The present invention provides antigen-binding proteins capable of binding to NKp46 polypeptides. The antigen-binding proteins have increased activity in the treatment of disorders characterized by NKp46-expressing cells, particularly tumor cells.

  本发明提供了能够与 NKp46 多肽结合的抗原结合蛋白。这些抗原结合蛋白在治疗以 NKp46 表达细胞，特别是肿瘤细胞为特征的疾病方面具有更高的活性。
• ENZYMATIC CONJUGATION OF POLYPEPTIDES
  申请人：Innate Pharma

  公开号：US20160331842A1

  公开（公告）日：2016-11-17

  The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.