N-Benzyl-N-methyl-2-aminoethyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate | 119666-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: N-Benzyl-N-methyl-2-aminoethyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate
• 英文别名: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester；5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 119666-09-0
• 化学式: C₃₀H₃₆N₄O₄
• 分子量: 516.64
• InChiKey: SCUPIRGJNHINID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Thiazolidinone derivatives, their preparation and their use
  申请人：Sankyo Company Limited

  公开号：EP0277836A1

  公开（公告）日：1988-08-10

  Thiazolidinone derivatives of formula (I): in which R¹, R², R³, R⁴ and R⁵ are various atoms or organic groups, Ar is an aromatic group and n, is an integer have valuable pharmacological activities including the ability to reduce blood glucose levels and blood lipid levels.

  式（I）的噻唑烷酮衍生物：其中 R¹、R²、R³、R⁴ 和 R⁵ 为各种原子或有机基团，Ar 为芳香基团，n 为整数，具有宝贵的药理活性，包括降低血糖和血脂水平的能力。
• Novel ABCA9 transporter and uses thereof
  申请人：Active Pass Pharmaceuticals, Inc.

  公开号：US20020123106A1

  公开（公告）日：2002-09-05

  The invention provides isolated nucleic acid molecules, designated ABCA9 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCA9 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an ABCA9 transporter gene has been introduced or disrupted. The invention further provides isolated ABCA9 transporter proteins, fusion proteins, antigenic peptides, anti-ABCA9 transporter antibodies, and screening assays for ABCA9 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

  本发明提供了编码新型 ABC 转运体家族成员的分离核酸分子，命名为 ABCA9 转运体核酸分子。本发明还提供了反义核酸分子、含有 ABCA9 转运体核酸分子的重组表达载体、导入表达载体的宿主细胞以及导入或破坏了 ABCA9 转运体基因的非人类转基因动物。本发明进一步提供了分离的 ABCA9 转运体蛋白、融合蛋白、抗原肽、抗 ABCA9 转运体抗体以及 ABCA9 转运体调节剂的筛选测定。还提供了利用本发明组合物的诊断和治疗方法。
• Novel ABCA5 transporter and uses thereof
  申请人：Active Pass Pharmaceuticals, Inc.

  公开号：US20020123107A1

  公开（公告）日：2002-09-05

  The invention provides isolated nucleic acid molecules, designated ABCA5 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCA5 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an ABCA5 transporter gene has been introduced or disrupted. The invention further provides isolated ABCA5 transporter proteins, fusion proteins, antigenic peptides, anti-ABCA5 transporter antibodies, and screening assays for ABCA5 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

  本发明提供了编码新型 ABC 转运体家族成员的分离核酸分子，命名为 ABCA5 转运体核酸分子。本发明还提供了反义核酸分子、含有 ABCA5 转运体核酸分子的重组表达载体、导入表达载体的宿主细胞以及导入或破坏了 ABCA5 转运体基因的非人类转基因动物。本发明进一步提供了分离的 ABCA5 转运体蛋白、融合蛋白、抗原肽、抗 ABCA5 转运体抗体以及 ABCA5 转运体调节剂的筛选测定。还提供了利用本发明组合物的诊断和治疗方法。
• Novel ABCG4 transporter and uses thereof
  申请人：Active Pass Pharmaceuticals, Inc.

  公开号：US20030027259A1

  公开（公告）日：2003-02-06

  The invention provides isolated nucleic acid molecules, designated ABCG4 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCG4 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an ABCG4 transporter gene has been introduced or disrupted. The invention further provides isolated ABCG4 transporter proteins, fusion proteins, antigenic peptides, anti-ABCG4 transporter antibodies, and screening assays for ABCG4 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

  本发明提供了编码新型 ABC 转运体家族成员的分离核酸分子，命名为 ABCG4 转运体核酸分子。本发明还提供了反义核酸分子、含有 ABCG4 转运体核酸分子的重组表达载体、导入表达载体的宿主细胞以及导入或破坏了 ABCG4 转运体基因的非人类转基因动物。本发明进一步提供了分离的 ABCG4 转运体蛋白、融合蛋白、抗原肽、抗 ABCG4 转运体抗体以及 ABCG4 转运体调节剂的筛选测定。还提供了利用本发明组合物的诊断和治疗方法。
• Regulation of amyloid precursor protein expression by modification of ABC transporter expression or activity
  申请人：Active Pass Pharmaceuticals, Inc.

  公开号：US20020169137A1

  公开（公告）日：2002-11-14

  The invention relates to the discovery that expression of amyloid precursor protein is regulated by the expression of an ABC transporter. The invention therefore provides methods and compositions for modulating amyloid precursor protein expression in a brain cell, thereby preventing or inhibiting pathological &bgr;-amyloid plaque formation in conditions such as Alzheimer's disease.

  本发明涉及淀粉样前体蛋白表达受 ABC 转运体表达调控的发现。因此，本发明提供了调节脑细胞中淀粉样前体蛋白表达的方法和组合物，从而预防或抑制阿尔茨海默病等病理&bgr;-淀粉样斑块的形成。